IgE in Atopic Dermatitis

Ogawa, Makio; Berger, Peter; McIntyre, O. Ross; Clendenning, William E.; Ishizaka, Kimishige

doi:10.1001/archderm.1971.04000180001001

Cited by 114 publications

(21 citation statements)

References 9 publications

(1 reference statement)

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“…(c) Recent studies in this laboratory with leukocytes from patients with atopic eczema (who have a strong genetic predisposition to asthma and allergic rhinitis but at the time of study had not had asthmatic symptoms or received catecholamine therapy) indicate a reduction in isoproterenol responsiveness of similar magnitude to that in individuals with active asthma (28). This finding is of considerable interest since patients with atopic eczema typically have increased serum IgE concentrations and many have bronchial hyper-reactivity to methacholine and histamine similar to that in patients with overt bronchial asthma (29,30). In one study the blood glucose response to epinephrine was reduced in these individuals (27).…”

Section: Resultsmentioning

confidence: 99%

Alterations in Cyclic Adenosine Monophosphate Metabolism in Human Bronchial Asthma. I. LEUKOCYTE RESPONSIVENESS TO β-ADRENERGIC AGENTS

Parker¹,

Smith²

1973

J. Clin. Invest.

282

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A B S T R A C T In an effort to better define the role of P-adrenergic blockade in human bronchial asthma, peripheral blood leukocytes and lymphocytes from individuals with this condition were studied for possible alterations in cyclic AMP metabolism. Using a previously described radioimmunoassay to measure cyclic AMP, cells from asthmatic subjects were shown to have a highly significant decrease in their cyclic AMP response to 8-adrenergic agents (isoproterenol, norepinephrine, and epinephrine) by comparison with normal control cells. The alteration in responsiveness was most marked at the time of severe active asthma and returned toward normal during periods of clinical remission. Evidence was presented to indicate that the reduced response in cells from asthmatic individuals was not due to marked alterations in the proportion of T and B lymphocytes. Five normal volunteers were treated with an oral bronchodilator preparation containing theophylline and ephedrine over a 2 wk period without a significant change in the lymphocyte cyclic AMP response.These results provide unambiguous evidence for altered adrenergic responsiveness in bronchial asthma and indicate that purified peripheral blood lymphocytes should be a suitable in vitro system for further elucidation of the abnormality.Despite the reduction in catecholamine responsiveness in the asthmatic population as a whole, major altera-

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Section: Resultsmentioning

confidence: 99%

Alterations in Cyclic Adenosine Monophosphate Metabolism in Human Bronchial Asthma. I. LEUKOCYTE RESPONSIVENESS TO β-ADRENERGIC AGENTS

Parker¹,

Smith²

1973

J. Clin. Invest.

282

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“…Finally, both mechanisms could contribute to increased serum IgE. Arguments supporting the first possibility come from clinical experience, showing that many different IgE specificities can be found in sera of AD patients [26], including autoreactivity. However, even testing against a very large panel of allergens reveals the specific IgE to represent only a minority of the total amount.…”

Section: Discussionmentioning

confidence: 99%

VH genes expressed in peripheral blood IgE-producing B cells from patients with atopic dermatitis

Tilgner

Golembowski

Kersten

et al. 1997

Clinical and Experimental Immunology

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SUMMARYIn this study we analysed the V H genes expressed in IgE-producing peripheral B cells in two patients with severe atopic dermatitis. We found a diverse antibody repertoire containing V H genes of five different V H families, no V H 2 and 7 genes, with no biased usage of one particular V H gene family. Some V H germ-line segments were found to be used several times within the e transcripts (V3-23, V3-30).Comparison of the IgE-encoding V H genes with the respective germ-line elements revealed the expression of nearly germ-line identical as well as somatically mutated V H genes. In these latter V H genes base substitutions were distributed over both complementarity determining and framework regions. Because of the similarities between the IgE committed B cell repertoire in atopic patients and the peripheral B cell repertoire in non-atopic individuals we conclude that the atopic V H gene repertoire probably reflects the result of an increased class switch of polyclonal B cells, including virgin and mature B cells, in response to a Th2 cytokine profile.

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“…It is released in response to activation of IgE receptors on these cell types or by stimulation with degranulating agents, such as complement components, neuropeptides, and cytokines. Production of IgE is closely related to allergic dermatitis and AD, and serum IgE levels have been reported to be elevated in allergic sensitization and AD patients compared with healthy individuals (Ogawa et al, 1971;Burrows et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of Lactococcus chungangensis inhibits 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in NC/Nga mice

Choi

Konkit

Kim

et al. 2016

Journal of Dairy Science

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Interest is increasing in the potentially beneficial role of probiotics in the prevention and treatment of atopic diseases. In this study, we investigated the protective effects of Lactococcus chungangensis CAU 28(T) against atopic dermatitis using murine macrophage RAW 264.7 cells, human keratinocyte HaCaT cells, human mast cell line HMC-1 cells, and a 2,4-dinitrochlorobenzene-induced atopic dermatitis model (NC/Nga mice). The results showed that L. chungangensis CAU 28(T) exhibited potent antiinflammatory activity by inhibiting the production of the proinflammatory mediators nitric oxide and prostaglandin E2 in lipopolysaccharide-stimulated RAW 264.7 cells. Treatment with L. chungangensis CAU 28(T) reduced the release of β-hexosaminidase and histamine in HMC-1 cells stimulated with mast cell activator compound 48/80. In addition, the back skin and ears of NC/Nga mice exhibited reduced histological manifestations of atopic skin lesions such as erosion, hyperplasia of the epidermis and dermis, and inflammatory cell infiltration. Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis. The findings indicate that L. chungangensis CAU 28(T) could be a novel probiotic candidate for controlling the symptoms of atopic dermatitis.

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IgE in Atopic Dermatitis

Cited by 114 publications

References 9 publications

Alterations in Cyclic Adenosine Monophosphate Metabolism in Human Bronchial Asthma. I. LEUKOCYTE RESPONSIVENESS TO β-ADRENERGIC AGENTS

Alterations in Cyclic Adenosine Monophosphate Metabolism in Human Bronchial Asthma. I. LEUKOCYTE RESPONSIVENESS TO β-ADRENERGIC AGENTS

VH genes expressed in peripheral blood IgE-producing B cells from patients with atopic dermatitis

Oral administration of Lactococcus chungangensis inhibits 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in NC/Nga mice

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