IgE in atopic dermatitis and other common dermatoses

Thymosin-inducible 'null' cells in atopic eczema

“…But for the eczema group in toto, there was a statistically significant (positive) correlation (Fig. 3) between plasma IgE levels and eczema severity, a trend already described by others (Rajka, 1961;Ogawa et al, 1971;Gurevitch, Heiner & Reisner, 1973;Stone et al, 1973;Jones, Inouye & McGerity, 1975;O'Loughlin et al, 1977).…”

Interleukin-2 Production of T Cells in Atopic Dermatitis

“…Many patients show high values of blood IgE and often have the complication of airway allergies such as bronchial asthma and allergic rhinitis (7). Such reports support the presence of type I allergy in these patients (1,2). However, it is well known that AD skin rashes are eczematous rather than wheal, and that cases show highly positive reactions in patch tests in which human dander is used as an antigen (3).…”

The Combination of Serum Total IgE and Blood Eosinophil Levels as a Predictor of Response to Phototherapy Treatment in Patients with Atopic Dermatitis

“…Te relationship between serum IgE levels and the severity of cutaneous involvement in patients with AD with coexisting atopic respiratory disease was directly recognized in previous studies [23,31]. However, establishing a link between IgE levels and cutaneous involvement has been proven to be more challenging [22,[32][33][34].…”

“…Stone et al evaluated 58 patients with a clinical diagnosis of AD in 1973 and showed a statistically signifcant relationship between serum IgE levels and the extent of skin involvement [21]. Gurevitch et al assessed the serum IgE levels in 147 patients with AD and other skin disorders; they reported a correlation of serum IgE levels with AD severity and demonstrated that IgE levels are signifcantly higher in patients with AD than in the nonatopic "control" patients [22]. A similar relationship was shown by Wüthrich in 1978 after studying 116 adult patients with AD, in which severe chronic cases showed the highest IgE values; however, among the patients with moderate or mild forms of AD, those with bronchial asthma or allergic rhinitis had higher IgE levels than those solely diagnosed with AD did [23].…”