IgE in atopic dermatitis and other common dermatoses

Gurevitch, Arnold W.

doi:10.1001/archderm.107.5.712

Cited by 39 publications

(17 citation statements)

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“…Serum IgE concentrations are high in atopy,[6] parasitosis,[7] human immunodeficiency virus infection,[8] systemic lupus erythematosus,[9] and certain types of cancer. [10] The production of IgE is usually Th2 cell determined.…”

Section: Introductionmentioning

confidence: 99%

Total serum immunoglobulin E in patients with alopecia areata

Bakry

Shazly

Basha

et al. 2014

Indian Dermatol Online J

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Context:Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The pathogenesis of the disease is unknown. Previous evidence suggested the involvement of Th2 cytokines in disease pathogenesis.Aim:To determine serum level of total IgE, this is mainly influenced by Th2 cytokines, in Egyptian patients with AA.Materials and Methods:Fifty subjects with AA (28 males and 22 females) were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital from February 2012 to December 2012. Subjects with other conditions that might elevate serum IgE were excluded from the study. Fifty age- and sex-matched healthy subjects were selected as a control group. Venous blood samples were taken from cases and controls for measurement of total serum IgE by enzyme-linked immunosorbent assay. Skin biopsy was taken from every case from an active area of hair loss.Results:Total serum IgE was elevated in 27 (54%) cases. Its values among patients ranged from 13.5 IU/ml to 780 IU/ml. There was a statistically significant difference between cases and controls with regard to mean value of serum IgE (P < 0.05). Mean value of IgE did not vary significantly with disease severity, patients’ age, patients’ gender, disease duration, site of lesions, and positive family history of AA. No correlation was found between serum IgE levels and histopathological changes detected in examined cases.Conclusions:Total serum IgE is elevated in AA. This elevation is not related to age, gender, disease duration, disease severity, site of affection or family history of AA.

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Section: Introductionmentioning

confidence: 99%

Total serum immunoglobulin E in patients with alopecia areata

Bakry

Shazly

Basha

et al. 2014

Indian Dermatol Online J

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“…A high serum IgE concentration is one of the critical characteristics of atopic diseases, such as atopic dermatitis, asthma and allergic rhinitis [1,2,3]. Clinical observations have suggested a mild correlation between serum IgE levels and the extent and/or severity of disease, especially with cutaneous lesions [4,5].…”

Section: Introductionmentioning

confidence: 99%

Hydrolyzed Konjac Glucomannan Suppresses IgE Production in Mice B Cells

Suzuki¹,

Oomizu²,

Yanase³

et al. 2009

Int Arch Allergy Immunol

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Background: Oral administration of pulverized Konjac glucomannan (KGM) reduces increased plasma IgE and the amount of Ε-germline transcript (ΕGT) in the spleen, as well as preventing the development of dermatitis in mice. To elucidate the mechanism of action of pulverized KGM, we solubilized KGM and studied its effect on IgE in vitro and in vivo. Methods: Solubilized KGM was prepared by acid hydrolysis, and we analyzed the effective molecular size for the suppression of IgE production and ΕGT in vitro and the level of plasma IgE induced by immunization with ovalbumin in BALB/c mice. Results: The production of IgE and ΕGT in splenic cells, but not purified B cells, was inhibited by hydrolyzed KGM (KGM hydrolyzed with 0.25 N HCl; H-KGM) at the optimal size of between 10 and 500 kDa. However, no effect was observed when H-KGM was substituted with unhydrolyzed KGM in vitro. IgE production from purified B cells cocultured with purified monocytes, but not with purified T cells, was inhibited by H-KGM. The release of IFNγ in cultures of monocytes but in purified B cells with or without T cells was enhanced in the presence of H-KGM. Injection of mice with H-KGM also suppressed the production of plasma IgE and IgG1 but not IgG2a in vivo. Conclusion: KGM at an optimal size prevents germline class-switching and IgE production both in vitro and in vivo. H-KGM may be useful as a tool to study the mechanism of action of KGM and as a dietary supplement to prevent atopic diseases.

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“…High concentrations of IgE in serum are consistently found in patients with atopic dermatitis and a correlation between the IgE level and the severity of atopic dermatitis has been proposed (4,7,13). In the present study, however, the fluctuations in IgE levels did not seem to correlate closely with the clinical status of the patients.…”

Section: Discussionmentioning

confidence: 99%

Long‐term Transfer Factor Treatment in Severe Atopic Dermatitis

Thulin

Ellegaard

Thestrup‐Pedersen

et al. 1977

Allergy

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Since Lawrence demonstrated that delayed hypersensitivity reactions in man could be transferred by viable leucocytes or extracts hereof, called transfer factor (TF) (lo), attempts to augment cell-mediated immune functions with TF have been made on patients with deficient cell-mediated immune reactivity. The main fields in which the clinical application of TF is used are infectious diseases (6, 9), immunodeficiency diseases (15) and malignancies (11, 20).In dermatology TF has been successfully used to intensify parameters of cell-mediated immune reactions in a patient with severe skin infection caused by Mycobacterium avium (17); also in generalized vaccinia treatment with TF seems to be of value (5). In mycosis fungoides additional treatment with TF was found promising (21).Within the last year two case reports have indicated a very successful use of TF in the treatment of severe atopic dermatitis in children (i, 16). We have treated three adults with severe atopic dermatitis and signs of depressed cell-mediated immune reactivity for a period of i V2 years. The present paper gives our results.

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IgE in atopic dermatitis and other common dermatoses

Cited by 39 publications

References 0 publications

Total serum immunoglobulin E in patients with alopecia areata

Total serum immunoglobulin E in patients with alopecia areata

Hydrolyzed Konjac Glucomannan Suppresses IgE Production in Mice B Cells

Long‐term Transfer Factor Treatment in Severe Atopic Dermatitis

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