1999
DOI: 10.1172/jci8205
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IgE in asthma and atopy: cellular and molecular connections

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Cited by 173 publications
(135 citation statements)
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References 30 publications
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“…2-4 are from the same experiment and followed the sensitization protocol shown in Fig. 1A. cells and basophils by allergen-specific IgE leads to the release of mediators that cause allergic reactions (16). Prominent among these is histamine, an intracellular mediator of the immediate hypersensitivity response that exerts potent effects on various target tissues.…”
Section: Pn-specific Ige Correlates With Anaphylactic Symptomsmentioning
confidence: 99%
“…2-4 are from the same experiment and followed the sensitization protocol shown in Fig. 1A. cells and basophils by allergen-specific IgE leads to the release of mediators that cause allergic reactions (16). Prominent among these is histamine, an intracellular mediator of the immediate hypersensitivity response that exerts potent effects on various target tissues.…”
Section: Pn-specific Ige Correlates With Anaphylactic Symptomsmentioning
confidence: 99%
“…I mmunoglobulin E plays a central role in the pathophysiology of allergic asthma and contributes to the inflammatory process, as indicated by findings in humans and mice that show a strong correlation between the level of IgE detected in the serum and bronchoalveolar lavage (BAL) 3 and the severity of the allergic airway inflammation that develops (1)(2)(3). Because of this correlation, the use of anti-IgE neutralizing Abs has become a very effective treatment for allergic asthma (4).…”
mentioning
confidence: 99%
“…This reaction is the key to IgE-mediated allergy (4). Moreover, the expression of these high-affinity receptors is probably up-regulated by IgE itself (5,6,7). Therefore, the concentration of circulating IgE does not reflect its true activity.…”
Section: Immunoglobulin Ementioning
confidence: 99%