IgE antibody against surface antigens of <i>Leishmania</i> promastigotes in American cutaneous leishmaniasis

Lynch, Neil R.; Malavé, Caridad; Turner, Keven J.; Infante, Benito

doi:10.1111/j.1365-3024.1986.tb00837.x

Cited by 8 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IgE antibodies bind strongly to promastigotes. [56][57][58] Immunoglobulins are associated with protection against malaria inoculation, by activating monocytes. The role of monocytes in malaria prophylaxis was first proposed by a research team from Uganda.…”

Section: The Skin Stage Of Malaria Infectionmentioning

confidence: 99%

An unexpected, revolutionary property of Artemisia infusions: immunoglobulins in the skin lead to a longlasting prophylaxis

Munyangi¹,

Gisenya²,

Ogwang³

et al. 2020

PPIJ

View full text Add to dashboard Cite

Naturally acquired immunity to malaria is a known phenomenon. But little is known about the underlying mechanisms. The majority of adults in sub-Saharan Africa rarely experience overt disease, despite they have a population of parasites in their blood that could prove lethal to a malaria-naïve visitor. The use of Artemisia herbal medicine is spreading in many African countries, in schools, health centers. It was shown 10 years ago in Uganda that regular drinking of infusions from Artemisia plants had a strong prophylactic effect. We were of the belief that this prophylaxis was going to last for a few days, maybe a few weeks. Over the last 2 months we received several surprising inputs indicating that this prophylaxis was lasting for months, even years. But more recently several partners also report that when Artemisia infusions or capsules have been used during 7 days to cure a malaria infection, the people having used this short-term treatment also experience a long-lasting prophylaxis. The most interesting research lead is that specific IgEs induced by Artemisia consumption remain for months in the skin. In this review paper we present several hypotheses to explain this revolutionary property of Artemisia plants, and more particularly Artemisia afra used since generations in many African countries against tropical diseases.

show abstract

Section: The Skin Stage Of Malaria Infectionmentioning

confidence: 99%

An unexpected, revolutionary property of Artemisia infusions: immunoglobulins in the skin lead to a longlasting prophylaxis

Munyangi¹,

Gisenya²,

Ogwang³

et al. 2020

PPIJ

View full text Add to dashboard Cite

show abstract

“…IgE antibodies bind strongly to promastigotes. 31 It happens that Artemisia infusions are less efficient for non-immune Caucasians. It is probably not related to genetic strains, but to the absence of acquired immunity.…”

Section: 16mentioning

confidence: 99%

Antibodies, prophylaxis, transmission

Lutgen¹

2018

PPIJ

View full text Add to dashboard Cite

Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation

et al. 2004

View full text Add to dashboard Cite

Immunoglobulin E (IgE) plays a critical role in both resistance to parasitic infection and allergy to environmental antigens. The IgE response is in turn regulated by the B-cell co-receptor CD23, and CD23-deficient mice show exaggerated IgE responses and airway hyper-responsiveness. In this report, we show that New Zealand black (NZB) mice express a variant CD23 allele, with mutations in both the C-lectin-binding domain and stalk region, which fails to bind IgE at high affinity and has reduced expression on the cell surface. Expression of the variant CD23 chain interferes with trimerisation of the receptor and has a dominant-negative effect leading to reduced IgE binding in crosses between NZB and other strains. Genetic mapping shows that the variant CD23 leads to an exaggerated primary IgE response, which is independent of other strain-specific effects. These results suggest that NZB mice or mice carrying the variant allele will be useful models for studying both allergy and quantitative traits associated with atopy. The exaggerated IgE response provides an explanation for the natural resistance of NZB mice to parasitic infection by Leishmania.

show abstract

IgE antibody against surface antigens of Leishmania promastigotes in American cutaneous leishmaniasis

Cited by 8 publications

References 26 publications

An unexpected, revolutionary property of Artemisia infusions: immunoglobulins in the skin lead to a longlasting prophylaxis

An unexpected, revolutionary property of Artemisia infusions: immunoglobulins in the skin lead to a longlasting prophylaxis

Antibodies, prophylaxis, transmission

Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation

Contact Info

Product

Resources

About