IgE and non-IgE food allergy

Sabrá, Aderbal; Bellanti, Joseph A.; Rais, Jonathan Malka; Castro, Henry; Inocencio, Julia Méndez de; Sabrá, Selma

doi:10.1016/s1081-1206(10)61664-x

Cited by 61 publications

(56 citation statements)

References 37 publications

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“…The IAR due to the IgE-mediated food allergy has been most extensively investigated [1,2,3,4,5,6,7,8,9,10,11,17,23,25,26,30,32,34,36,37,40,43]. The LAR to foods has also been reported, but its immunological mechanism has not yet been sufficiently clarified [2,9,10,14,17,18,23,26,27,38].…”

Section: Discussionmentioning

confidence: 99%

“…Food allergy is a multifaceted clinical manifestation of an immunological process in which foods or their components act as antigens, stimulating the production of specific antibodies or sensitizing the particular T lymphocyte subsets and subsequently interacting with them [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. Food allergy was previously classically attributed to the involvement of the immediate (IgE-mediated) hypersensitivity mechanism [1,2,3,4,5,6,7,8,9,10,11,17,22,23,25,26,27,28,29,30,31,32,33,34].…”

Section: Introductionmentioning

confidence: 99%

“…Food allergy was previously classically attributed to the involvement of the immediate (IgE-mediated) hypersensitivity mechanism [1,2,3,4,5,6,7,8,9,10,11,17,22,23,25,26,27,28,29,30,31,32,33,34]. However, evidence has been found for the possible involvement of other, so-called non-IgE-mediated, hypersensitivity types, such as late (immune-complex-mediated) and delayed (cell-mediated) types of hypersensitivity in food allergy [1,3,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. Food allergy can also be a factor in disorders of the respiratory tract, such as bronchial asthma [1,2,3,4,8,9,10,11,21,23,24,25,26,27,28,29,30,31,34,35,36].…”

Section: Introductionmentioning

confidence: 99%

“…Food-induced IAR, LAR, DAR and DYAR differ from each other with respect to their clinical features, their association with other diagnostic parameters and to the possible underlying immunological mechanisms [1,2,3,4,9,12,13,14,15,16,17,18,19,23,25,26,27,30,32,34,40,42,43]. The provocation tests with foods should be considered to be the definite confirmation of the contribution of a certain food to the patient’s complaints, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Asthmatic Response to Milk Ingestion Challenge in Adults: A Comparison of the Open and Double-Blind Challenges

Pelikán¹

2013

Int Arch Allergy Immunol

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Background: Cow’s milk allergy can participate in pathophysiological mechanisms underlying bronchial asthma in some adult patients. This role should ultimately be confirmed by means of a milk ingestion challenge. In this study, the diagnostic value of the open food ingestion challenge (OFICH) and the double-blind placebo-controlled food challenge (DBPCFC) techniques with milk were compared in adult patients suffering from bronchial asthma with suspected milk allergy. Methods: In 87 asthmatics with a suspected history and positive skin tests for milk, the 87 OFICHs and DBPCFCs were performed in combination with spirometry and followed up to 72 h after the challenge. Results: Of 87 patients, 74 (85%) developed a positive asthmatic response (AR) (20 immediate, 33 late, 6 dual late and 15 delayed; p < 0.01) and 13 (15%) developed a negative AR (p > 0.1) to OFICH. Seventy-five (86%) developed a positive AR (17 immediate, 35 late, 8 dual late and 15 delayed; p < 0.01) and 12 (14%) developed a negative AR (p > 0.05) to DBPCFC. The correlation between the OFICH and DBPCFC was statistically significant (p < 0.01). All placebo control challenges were negative (p > 0.2). Conclusions: In some adults with bronchial asthma, involvement of an allergy to cow’s milk results in the appearance of various AR types (immediate, late, dual late or delayed). The milk allergy can be confirmed by open or double-blind techniques, combined with spirometry. No significant differences were found between the OFICH and DBPCFC results. OFICH with natural milk combined with spirometry seems, therefore, to be an adequate technique for the detection of milk allergy in asthmatics. The DBPCFC can be performed as an additional check, if necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Asthmatic Response to Milk Ingestion Challenge in Adults: A Comparison of the Open and Double-Blind Challenges

Pelikán¹

2013

Int Arch Allergy Immunol

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“…Although the immune responses of the gastrointestinal tract are frequently directed towards the exclusion of microbial pathogens, they also function in the containment of certain ingested allergenic proteins [15, 16]. It is not known how allergens, particularly latex proteins, are handled by the intestines of mice.…”

Section: Introductionmentioning

confidence: 99%

Gastro-Intestinal Exposure to Latex Antigens Induce Allergic Responses in Mice

Barrios

Kurup

Rickaby

et al. 2006

Int Arch Allergy Immunol

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Background: Natural rubber latex (NRL) has emerged as a major cause of respiratory allergy among specific exposed groups of individuals. Since latex allergens are dispersed in the environment it is conceivable that latex proteins are both inhaled and ingested. The mechanism of latex allergy and the immune responses following reexposure of latex allergens by the intranasal route was studied in a murine model of latex allergy developed by intragastric sensitization with NRL. Methods:BALB/c mice were sensitized intragastrically (‘ig’), intranasally (‘in’) or ‘ig’ followed by ‘in’ challenge with NRL allergens. The cellular and humoral immune responses, lung function and histological changes were determined. Results: Peripheral blood eosinophilia was observed in the ‘ig’ and ‘ig/in’-NRL-sensitized animals in comparison to normal controls (p < 0.05). The ‘ig’ group showed a marked increase over control mice in serum total IgE, NRL-specific IgG and IgG subclasses (p < 0.05). Increased levels of IL-4, IL-5, IL-10, and IL-13 were detected in ‘ig’-NRL-sensitized mice. Intranasal exposure with NRL after ‘ig’ sensitization further enhanced the cytokine levels. A tendency towards enhanced stimulation was determined in ‘ig’-sensitized mice; a significant difference was shown in the ‘ig/in’-group (p < 0.05). Increased airway hyperreactivity was found in ‘ig’-NRL-sensitized-mice (15.1 ± 2.5 vs. 8.9 ± 1.7 cm H₂O·ml^–1·s, p < 0.05). Mucus secretion from jejunal epithelium and eosinophilic infiltration into the jejunal lamina propria were observed in the ‘ig’-NRL-sensitized-mice. Conclusions:The results demonstrate that intragastric NRL sensitization did not induce specific tolerance, and additional intranasal exposure with latex allergens resulted in systemic allergic manifestations in the murine model.

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P0013 Pp Abnormalities in Cd8 Function in Non‐ige Food Allergy: A New Relationship?

Sabra,

Bellanti

2004

J. pediatr. gastroenterol. nutr.

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IgE and non-IgE food allergy

Cited by 61 publications

References 37 publications

Asthmatic Response to Milk Ingestion Challenge in Adults: A Comparison of the Open and Double-Blind Challenges

Asthmatic Response to Milk Ingestion Challenge in Adults: A Comparison of the Open and Double-Blind Challenges

Gastro-Intestinal Exposure to Latex Antigens Induce Allergic Responses in Mice

P0013 Pp Abnormalities in Cd8 Function in Non‐ige Food Allergy: A New Relationship?

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