IGE and Monoclonal Antibody Reactivities to the Major Shrimp Allergen Pen a 1 (Tropomyosin) and Vertebrate Tropomyosins

Reese, Gerald; Tracey, Deborah; Daul, C.B.; Lehrer, Samuel B.

doi:10.1007/978-1-4615-5855-2_31

Cited by 13 publications

(4 citation statements)

References 10 publications

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“…Allergic reactions are most likely (and also are most studied) to the proteins of shrimps— tropomyosin (Pen a 1) [39], of fishes—, the cod allergen Cad c 1 [40, 41], and the perch allergen [42]. …”

Section: Resultsmentioning

confidence: 99%

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Golokhvast

2014

Journal of Immunology Research

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This paper presents an analysis of airborne biogenic particles (1 mkm–1 mm) found in the snow in several cities of the Russian Far East during 2010–2013. The most common was vegetational terraneous detritus (fragments of tree and grass leaves) followed by animal hair, small insects and their fragments, microorganisms of aeroplankton, and equivocal biological garbage. Specific components were found in samples from locations close to bodies of water such as fragments of algae and mollusc shells and, marine invertebrates (needles of sea urchins and shell debris of arthropods). In most locations across the Far East (Vladivostok, Khabarovsk, Blagoveshchensk, and Ussuriysk), the content of biogenic particles collected in the winter did not exceed 10% of the total particulate matter, with the exception of Birobidzhan and the nature reserve Bastak, where it made up to 20%. Most of all biogenic compounds should be allergic: hair, fragments of tree and grass leaves, insects, and microorganisms.

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Section: Resultsmentioning

confidence: 99%

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Golokhvast

2014

Journal of Immunology Research

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“…However, these allergens from invertebrate origin show lower homology with vertebrate tropomyosins (~45% identity). The lack of cross-reactivity between vertebrate and invertebrate tropomyosins would be explained by the presence of IgE binding epitopes in parts of the allergen non-homologous to the vertebrate tropomyosins [83,88].…”

Section: Cockroach Allergens With Homology To Proteins Involved In Comentioning

confidence: 99%

Cockroach Allergens: Function, Structure and Allergenicity

Pomés

Wünschmann²,

Hindley³

et al. 2007

PPL

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“…Dot blot and immunoblot analysis on subjects with a history of meat allergy to vertebrate meats did not show any IgE binding to tropomyosin of beef, pork, rabbit or chicken [19,20]. Similar studies demonstrated that shrimp allergic subjects' specific IgE did not cross react with any mammalian tropomyosins or their fragments [18,21]. …”

Section: Introductionmentioning

confidence: 95%

Not all shellfish “allergy” is allergy!

Woo

Bahna

2011

Clinical & Translational All

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The popularity of shellfish has been increasing worldwide, with a consequent increase in adverse reactions that can be allergic or toxic. The approximate prevalence of shellfish allergy is estimated at 0.5-2.5% of the general population, depending on degree of consumption by age and geographic regions. The manifestations of shellfish allergy vary widely, but it tends to be more severe than most other food allergens.Tropomyosin is the major allergen and is responsible for cross-reactivity between members of the shellfish family, particularly among the crustacea. Newly described allergens and subtle differences in the structures of tropomyosin between different species of shellfish could account for the discrepancy between in vitro cross-antigenicity and clinical cross-allergenicity. The diagnosis requires a thorough medical history supported by skin testing or measurement of specific IgE level, and confirmed by appropriate oral challenge testing unless the reaction was life-threatening.Management of shellfish allergy is basically strict elimination, which in highly allergic subjects may include avoidance of touching or smelling and the availability of self-administered epinephrine. Specific immunotherapy is not currently available and requires the development of safe and effective protocols.

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IGE and Monoclonal Antibody Reactivities to the Major Shrimp Allergen Pen a 1 (Tropomyosin) and Vertebrate Tropomyosins

Cited by 13 publications

References 10 publications

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Airborne Biogenic Particles in the Snow of the Cities of the Russian Far East as Potential Allergic Compounds

Cockroach Allergens: Function, Structure and Allergenicity

Not all shellfish “allergy” is allergy!

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