IgE and IgG4 antibody responses to Aedes saliva in African children

Remoué, Franck; Alix, Eric; Cornélie, Sylvie; Sokhna, Cheikh; Cissé, Badara; Doucouré, Souleymane; Mouchet, François; Boulanger, Denis; Simondon, François

doi:10.1016/j.actatropica.2007.07.011

Cited by 54 publications

(62 citation statements)

References 20 publications

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“…22 Such results were close to those obtained in individuals exposed to the bites of Aedes . [23][24][25][26] In all these studies, the presence of IgG4 antibodies was correlated to the production of IgE antibodies suggesting that IgG4 was the result of an allergic reaction to mosquitoe bites. Contrasting with such data, we did not find any correlation between the presence of specific IgG4 and IgE antibodies in our cohort suggesting that the prominence of IgG4 anti-saliva antibodies did not reflect an allergic response (hypersensitivity type I) to sand fly bites.…”

Section: Discussionmentioning

confidence: 89%

Characterization of the Antibody Response to the Saliva of Phlebotomus papatasi in People Living in Endemic Areas of Cutaneous Leishmaniasis

Marzouki¹,

Ahmed²,

Boussoffara³

et al. 2011

The American Society of Tropical Medicine and Hygiene

109

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Important data obtained in mice raise the possibility that immunization against the saliva of sand flies could protect from leishmaniasis. Sand fly saliva stimulates the production of specific antibodies in individuals living in endemic areas of parasite transmission. To characterize the humoral immune response against the saliva of Phlebotomus papatasi in humans, we carried out a prospective study on 200 children living in areas of Leishmania major transmission. We showed that 83% of donors carried anti-saliva IgG antibodies, primarily of IgG4 isotype. Positive sera reacted differentially with seven salivary proteins. The protein PpSP30 was prominently recognized by all the sera. The salivary proteins triggered the production of various antibody isotypes. Interestingly, the immunodominant PpSP30 was recognized by all IgG subclasses, whereas PpSP12 was not by IgG4. Immunoproteomic analyses may help to identify the impact of each salivary protein on the L. major infection and to select potential vaccine candidates.

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Section: Discussionmentioning

confidence: 89%

Characterization of the Antibody Response to the Saliva of Phlebotomus papatasi in People Living in Endemic Areas of Cutaneous Leishmaniasis

Marzouki¹,

Ahmed²,

Boussoffara³

et al. 2011

The American Society of Tropical Medicine and Hygiene

109

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“…aegypti saliva were also considered to be a surrogate biomarker for exposure in travelers, suggesting that antibody testing could be relevant to short-term exposure. 26 Remoue and others showed that IgG responses to Aedes saliva could reflect the exposure of human populations in the developing world: 27 IgE and IgG4 responses to Ae. aegypti saliva were detected in young children in Senegal living in an arbovirus-endemic area (dengue, yellow fever, chikungunya).…”

mentioning

confidence: 99%

Human Antibody Response to Aedes aegypti Saliva in an Urban Population in Bolivia: A New Biomarker of Exposure to Dengue Vector Bites

Doucouré¹,

Mouchet²,

Cournil³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher Ae. aegypti density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to Aedes bites.

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“…This first approach suggests that the evaluation of anti-saliva IgG response could discriminate the difference of Glossina exposure according to studied site, as previously described for Aedes exposure. 7 Nevertheless, further studies including entomologic assessments of precise Glossina exposure are necessary to confirm these results according to different levels of exposure.…”

Section: Resultsmentioning

confidence: 99%

“…4,5 Studies on different vectors (Triatoma, Aedes, Phlebotomus, Anopheles) have suggested that the evaluation of human specific Ab response to saliva and/or to recombinant salivary protein could evaluate the exposure of individuals to vector bites and thus could be an indicator of risk to pathogens transmission. [6][7][8][9] Few studies have explored the immune properties of Glossina saliva. 10 Previous study indicated that IgG response to Glossina morsitans morsitans saliva and to specific salivary Tsal proteins were detected in exposed and infected Ugandan populations.…”

Section: Introductionmentioning

confidence: 99%

Human IgG Antibody Response to Glossina Saliva: An Epidemiologic Marker of Exposure to Glossina Bites

Poinsignon

Remoué²,

Rossignol³

et al. 2008

The American Journal of Tropical Medicine and Hygiene

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Abstract. The evaluation of human antibody response specific to arthropod saliva may be a useful marker of exposure to vector-borne disease. Such an immunologic tool, applied to the evaluation of the exposure to Glossina bites, could be integrated in the control of human African trypanosomiasis (HAT). The antibody (IgG) response specific to uninfected Glossina fuscipes fuscipes saliva was evaluated according to the vector exposure and trypanic status in individuals residing in an HAT-endemic area. A high level of anti-saliva IgG antibodies was only detected in exposed individuals, whether infected or not by Trypanosoma brucei gambiense. In addition, the evaluation of specific IgG response represented spatial heterogeneity according to studied sites. These results suggest that the evaluation of anti-saliva IgG could be an indicator of Glossina exposure and thus could be integrated in other available tools to identify populations presenting risks of HAT transmission.

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IgE and IgG4 antibody responses to Aedes saliva in African children

Cited by 54 publications

References 20 publications

Characterization of the Antibody Response to the Saliva of Phlebotomus papatasi in People Living in Endemic Areas of Cutaneous Leishmaniasis

Characterization of the Antibody Response to the Saliva of Phlebotomus papatasi in People Living in Endemic Areas of Cutaneous Leishmaniasis

Human Antibody Response to Aedes aegypti Saliva in an Urban Population in Bolivia: A New Biomarker of Exposure to Dengue Vector Bites

Human IgG Antibody Response to Glossina Saliva: An Epidemiologic Marker of Exposure to Glossina Bites

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