IGBT-Based Pulsed Electric Fields Generator for Disinfection: Design and In Vitro Studies on Pseudomonas aeruginosa

Rubin, Andrey Ethan; Levkov, Klimenty; Usta, O. Berk; Yarmush, Martin L.; Golberg, Alexander

doi:10.1007/s10439-019-02225-0

Cited by 9 publications

(3 citation statements)

References 63 publications

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“…The pulse delivery is normally controlled with a semiconductor switch. Depending on the switch type or driving mode, the waveform is either rectangular (using metal-oxide-semiconductor field-effect transistors (MOSFETs) and insulated-gate bipolar transistors (IGBTs) [44]) or exponential decay wave (older concept typically used with thyristors [45]). In case of exponential decay pulses, the duration of the pulse (decay time) is defined by RC parameters of the discharge circuit, while in the case of rectangular pulses the parameters are mostly limited by the switch capabilities and the discharge capacitor value.…”

Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%

Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art

et al. 2020

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Electroporation is a pulsed electric field triggered phenomenon of cell permeabilization, which is extensively used in biomedical and biotechnological context. There is a growing scientific demand for high-voltage and/or high-frequency pulse generators for electropermeabilization of cells (electroporators). In the scope of this article we have reviewed the basic topologies of nanosecond pulsed electric field (nsPEF) generators for electroporation and the parametric capabilities of various in-house built devices, which were introduced in the last two decades. Classification of more than 60 various nsPEF generators was performed and pulse forming characteristics (pulse shape, voltage, duration and repetition frequency) were listed and compared. Lastly, the trends in the development of the electroporation technology were discussed.

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Section: Pulse Forming Using Capacitor Discharge Circuitsmentioning

confidence: 99%

Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art

et al. 2020

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“…The pulse delivery is normally controlled with a semiconductor switch. Depending on the switch type or driving mode, the waveform is either square (using metal-oxidesemiconductor field-effect transistors (MOSFETs) and insulated-gate bipolar transistors (IGBTs) (Rubin et al 2019)) or exponential decay wave (older concept typically used with thyristors (Ping et al 2003)). In case of exponential decay pulses, the duration of the pulse (decay time) is defined by RC parameters of the discharge circuit, while in the case of square-wave pulses the parameters are mostly limited by the switch capabilities and the discharge capacitor value.…”

Section: Capacitor Discharge Pulse Generatormentioning

confidence: 99%

Research and development of the high-frequency square-wave pulse electroporation system

Butkus¹

2020

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“…While there are several techniques to generate high-voltage pulses, being the direct capacitive discharge [19], the use of transformer [20], pulse forming lines [21], and inductive energy storage [22] methods some of them. The requirement for 100 s ns to 100 s µs pulse variation narrows the selection to direct capacitive discharge [1].…”

Section: Introductionmentioning

confidence: 99%

Four Channel 6.5 kV, 65 A, 100 ns–100 µs Generator with Advanced Control of Pulse and Burst Protocols for Biomedical and Biotechnological Applications

Kandratsyeu

Sabaleuski²,

Redondo

et al. 2021

Applied Sciences

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Pulsed electric fields in the sub-microsecond range are being increasingly used in biomedical and biotechnology applications, where the demand for high-voltage and high-frequency pulse generators with enhanced performance and pulse flexibility is pushing the limits of pulse power solid state technology. In the scope of this article, a new pulsed generator, which includes four independent MOSFET based Marx modulators, operating individually or combined, controlled from a computer user interface, is described. The generator is capable of applying different pulse shapes, from unipolar to bipolar pulses into biological loads, in symmetric and asymmetric modes, with voltages up to 6.5 kV and currents up to 65 A, in pulse widths from 100 ns to 100 µs, including short-circuit protection, current and voltage monitoring. This new scientific tool can open new research possibility due to the flexibility it provides in pulse generation, particularly in adjusting pulse width, polarity, and amplitude from pulse-to-pulse. It also permits operating in burst mode up to 5 MHz in four independent channels, for example in the application of synchronized asymmetric bipolar pulses, which is shown together with other characteristics of the generator.

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IGBT-Based Pulsed Electric Fields Generator for Disinfection: Design and In Vitro Studies on Pseudomonas aeruginosa

Cited by 9 publications

References 63 publications

Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art

Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art

Research and development of the high-frequency square-wave pulse electroporation system

Four Channel 6.5 kV, 65 A, 100 ns–100 µs Generator with Advanced Control of Pulse and Burst Protocols for Biomedical and Biotechnological Applications

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