IgA pemphigus: A case report and its characteristic clinical features compared with subcorneal pustular dermatosis

Niimi, Yayoi; Kawana, Seiji; Kusunoki, Toshio

doi:10.1067/mjd.2000.107478

Cited by 26 publications

(14 citation statements)

References 30 publications

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“…Previously reported atypical IGAP cases are summarized in Table 1. Further underscoring the complexity of IGAP, several cases have been reported with positive direct and indirect immunofluorescence evidence for IgA autoantibodies, but no reactivity to either Dsc or Dsg, [13][14][15] suggesting the existence of other, not yet identified, cell surface autoantigens in IGAP. [10][11][12] A review of the literature indicates that SPD-like features can be associated with IgA antibodies targeting autoantigens other than Dsc1, whereas IgA reactivity against Dsc1 does not necessarily result in subcorneal pustule formation.…”

Section: Discussionmentioning

confidence: 99%

The expanding spectrum ofIgApemphigus: a case report and review of the literature

et al. 2014

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IgA pemphigus (IGAP) is a rare, distinct variant of pemphigus, currently classified, depending upon the histological features, immunofluorescence staining pattern and autoantibody profile, into two types: subcorneal pustular dermatosis (SPD) and intraepidermal neutrophilic IgA dermatosis. In a patient with a widespread blistering disease of the skin resembling SPD-type IGAP, we demonstrate the coexistence of IgA reactivity to both epidermal (desmocollins 2 and 3) and basement membrane-associated (BP180) proteins, suggesting the coexistence of atypical IGAP and linear IgA bullous dermatosis, respectively. This case, together with 20 previous reports of atypical IGAP, underscores the limitations of current classification schemes. Therefore, we suggest reclassifying these cases under the general term 'IGAP spectrum'.

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Section: Discussionmentioning

confidence: 99%

The expanding spectrum ofIgApemphigus: a case report and review of the literature

et al. 2014

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“…To date, many cases of vesiculopustular lesions and IgA class autoantibodies against keratinocytes' surface have been reported in the published work, IgA pemphigus is the most widely used term at present. 5,6 IgA pemphigus possesses clinical and histopathological heterogeneity and is classified into two distinct subtypes: subcorneal pustular dermatosis (SPD) type and intraepidermal neutrophilic IgA dermatosis (IEN) type. 1,7,8 Immunoglobulin A pemphigus usually occurs in middle-aged or elderly persons.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin A pemphigus associated with immunoglobulin A gammopathy and lung cancer

Petropoulou

Politis

Panagakis

et al. 2008

The Journal of Dermatology

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Immunoglobulin (Ig)A pemphigus is a rare disease marked by a vesiculopustular eruption characterized by intercellular IgA deposition in the epidermis. It has clinical and histopathological heterogeneity and encompasses two subgroups: subcorneal pustular dermatosis type and intraepidermal neutrophilic IgA dermatosis type. IgA pemphigus has been rarely associated with monoclonal IgA paraprotein, myeloma and B-cell lymphoma in the past. We report the first case, to our knowledge, of a 47-year-old male patient with a subcorneal pustular dermatosis type of IgA pemphigus associated with IgA gammopathy and lung cancer.

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“…Cases clinically simulating SPD but showing epidermal IgA deposition and concurrent circulating IgA antibodies have been reported and are called intraepidermal IgA pustulosis, intraepidermal neutrophilic IgA dermatosis, IgA pemphigus, or intercellular IgA dermatosis (3,5,6). SPD commonly involves the axillae, groin, and inframammary area, while the lesions of IgA pemphigus usually involve the scalp and the face (7). Direct and indirect immunofluorescence studies can be useful in the differentiation of these two clinically similar disorders (7).…”

Section: Discussionmentioning

confidence: 99%

“…SPD commonly involves the axillae, groin, and inframammary area, while the lesions of IgA pemphigus usually involve the scalp and the face (7). Direct and indirect immunofluorescence studies can be useful in the differentiation of these two clinically similar disorders (7). In our case, direct and indirect immunofluorescence studies did not show deposition of immunoglobulins or complement (7).…”

Section: Discussionmentioning

confidence: 99%

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Juvenile Subcorneal Pustular Dermatosis: A Case Report

Koçak¹,

Bırol²,

Erkek³

et al. 2003

Pediatric Dermatology

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Subcorneal pustular dermatosis is a chronic, relapsing, pustular dermatosis that usually develops in elderly women. It is rarely seen in childhood and adolescence. The hallmark of the disease is formation of a subcorneal pustule detected on histopathologic examination. Herein we present a 13-year-old girl diagnosed with subcorneal pustular dermatosis based on the typical clinical and histologic findings. Direct and indirect immunofluorescence and serum protein electrophoresis had negative results. The patient partially recovered after 5 weeks of treatment consisting of oral dapsone and a topical steroid ointment.

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IgA pemphigus: A case report and its characteristic clinical features compared with subcorneal pustular dermatosis

Cited by 26 publications

References 30 publications

The expanding spectrum ofIgApemphigus: a case report and review of the literature

The expanding spectrum ofIgApemphigus: a case report and review of the literature

Immunoglobulin A pemphigus associated with immunoglobulin A gammopathy and lung cancer

Juvenile Subcorneal Pustular Dermatosis: A Case Report

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