IgA nephropathy in a patient with IgG myeloma

Lakshmi, B. V.; Devi, S V Padmavathi; Sameera, N Sai; Reddy, AS; Ram, R; Kumar, V Siva

doi:10.4103/ijn.ijn_377_17

Cited by 2 publications

(6 citation statements)

References 10 publications

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“…It is also possible that both the malignancy and the glomerular disease are expressions of an altered immune response to common inciting antigens. [ 1 3 7 ]…”

Section: Discussionmentioning

confidence: 99%

Association of IgA nephropathy with squamous cell carcinoma of the tongue: – Case report and review of literature

et al. 2021

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A 32-year-old habitual tobacco chewer was diagnosed with squamous cell carcinoma of the tongue. He was initiated on chemo-radiation therapy. After completing 23 cycles of radiation and four cycles of cisplatin-based chemotherapy, he presented with acute nephritic syndrome. Renal biopsy showed IgA nephropathy and acute tubular injury. With supportive care, renal function stabilised with a reduction in proteinuria. We wish to highlight the poorly understood association between mucosal malignancies and IgA nephropathy. It is also interesting to note the peculiar temporal profile of glomerular involvement in our patient, where the onset of the glomerulonephritis was after the initiation of chemo-radiotherapy. This is unlike what has been described earlier.

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“…It is also possible that both the malignancy and the glomerular disease are expressions of an altered immune response to common inciting antigens. [ 1 3 7 ]…”

Section: Discussionmentioning

confidence: 99%

Association of IgA nephropathy with squamous cell carcinoma of the tongue: – Case report and review of literature

et al. 2021

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“… 6 – 9 To the best of our knowledge, there are only four case reports of IgAN in patients with IgG MM. 6 , 10 , 11 …”

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confidence: 99%

“…To the best of our knowledge this is the fifth reported case of the unusual association between IgG MM and IgA nephropathy, emphasizing the need for an accurate diagnosis and a multidisciplinary approach to MM patients, especially when renal dysfunction develops. 6 , 7 , 10 , 11 …”

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confidence: 99%

“…[6][7][8][9] To the best of our knowledge, there are only four case reports of IgAN in patients with IgG MM. 6,10,11 A 54-year-old woman was diagnosed with plasmacytoma on the left hip in 2002, and treated with local radiotherapy. In 2007, she developed MM (IgG kappa type) ISS1 treated with idarubicin and dexamethasone, followed by an autologous stem cell transplant, achieving complete response.…”

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confidence: 99%

“…A default in IgA1 0-glycosylation is the main underlying mechanism, contributing to glomerular inflammation and mesangial proliferation 6–9 . To the best of our knowledge, there are only four case reports of IgAN in patients with IgG MM 6,10,11 …”

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confidence: 99%

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IgA nephropathy in IgG kappa multiple myeloma

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et al. 2021

Porto Biomedical Journal

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Multiple myeloma (MM) frequently affects kidney function through multiple mechanisms. Nonetheless, some patients develop kidney injury due to other causes. A 54-year-old woman was diagnosed with IgG kappa MM developed IgA nephropathy without cast nephropathy. Further studies did not show criteria for MM progression or other causes. This case highlights the need for further investigation of kidney injury in MM patients (such as toxicity of previous drugs, infectious events, or immune-mediated disorders).

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IgA nephropathy in a patient with IgG myeloma

Cited by 2 publications

References 10 publications

Association of IgA nephropathy with squamous cell carcinoma of the tongue: – Case report and review of literature

Association of IgA nephropathy with squamous cell carcinoma of the tongue: – Case report and review of literature

IgA nephropathy in IgG kappa multiple myeloma

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