IgA nephropathy associated with polycythaemia vera: accelerated course

Abstract

attacks and urolithiasis from the age of 27 years, along pathy; platelet aggregation; polycythaemia vera with mild proteinuria and haematuria and mild polycythaemia 5 years before admission, blood values were haematocrit (Htc) 52%, white blood cell count 13 000/ml, red blood cell (RBC) count 5 600 000/ml, Case report On admission, he presented with a reddish face, injected conjunctivae, and moderate hepatosplenome-Patient 1 a 35-year-old Japanese male, was referred to galy. Neurological signs and the findings on head CT our hospital in June 1994 because of a hypertensive scan were consistent with cranial nerves VIII and IX crisis (224/140 mmHg) with headache, visual disturbdamage due to cerebral infarction. Repeated and freance, and dark urine. He had been normotensive until quent blood pressure measurements were within March 1994 when he developed an upper respiratory normal limits. infection. His past history included recurrent gout Urinalysis in both cases demonstrated intense proteinuria (patient 1, 4.0 g/day; patient 2, 2.8 g/day) and Correspondence and offprint requests to: Eri Muso MD, Third haematuria (20-40 RBCs; 30-40 RBCs per high-power Division, Department of Internal Medicine, Faculty of Medicine, field in the sediments respectively) with numerous RBC

Polycythemia vera associated with IgA nephropathy: A case report and literature review

“…Hypertension was observed in all cases. A hypertension crisis occurred in 1 case (5). With respect to patient follow-up, 5 cases (23.8%) progressed to end stage renal disease (ESRD) and required routine dialysis.…”

“…The numbers of cases of normal, moderate and severe renal dysfunction were 2 (25%), 4 (50%) and 1 (12.5%), respectively. All 8 patients presented with hypertension, including 1 case with a hypertension crisis that was diagnosed histopathologically as mesangial proliferative glomerulonephritis (MsPGN), global glomerulosclerosis and necrotizing arteritis (5). Two cases also presented with hyperuricemia (8,9) and 1 case with cerebral infarction (5).…”

End-Stage Renal Disease following Polycythemia vera: In vitro and in vivo Response of Erythroid Progenitors to Erythropoietin and Effects of Sera on Normal Erythropoiesis

“…Secondary erythrocytosis due to hypoxia or increased EPO production was excluded by appropriate tests in our patients. Patients with PV have been occasionally reported in association with parenchymal renal disease in which the renal function was only minimally impaired [14, 15, 16]. There were totally 7 cases of well-documented PV associated with terminal renal failure in the review of the literature (table 3).…”

IgA Nephropathy in a Patient with Polycythemia vera

“…Although several reports have presented secondary erythrocytosis associated with renal glomerular diseases [2][3][4][5][6], simultaneous occurrence of PV and glomerular diseases in the same patient has rarely been published in the English literature. Only a few reports described PV associated with diffuse mesangial proliferative glomerulonephritis (GN) [7], Henoch-Schönlein purpura (HSP) nephritis [8], focal segmental glomerulosclerosis (FSGS) [9,10], and IgA nephropathy (IgAN) [11]. In spite of IgAN being the most common GN worldwide, there have been only 2 cases of IgAN in patients with PV [11].…”