IgA Nephropathy and Spinal Epidural Abscess After COVID-19 Infection: A Case Report

Göre, Burak; Yenigun, Ezgi Coskun; Cevher, Şimal Köksal; Çankaya, Emre; Aydın, Numan; Dede, Fatih

doi:10.2217/fvl-2021-0314

Cited by 8 publications

(9 citation statements)

References 21 publications

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“…This case illustrates a 60-year-old man with gingivitis and immunocompromise related to diabetes who developed multi-focal cervical and lumbar pyogenic infection (ie, paraspinal, psoas, and epidural abscesses) shortly after COVID-19 illness. Accordingly, this case reinforces previous associations between immunocompromise and opportunistic pyogenic spinal infection [ 5 ], and adds to the growing literature showing that COVID-19 illness is another potential risk factor for these types of infections [ 11 – 17 ].…”

Section: Discussionsupporting

confidence: 85%

“…According to a Search of PubMed and Google Scholar on August 17, 2022, and citation tracking of identified articles, 15 cases of pyogenic spinal infection occurring in patients with Coronavirus Disease 2019 (COVID-19) had been published [ 11 – 17 ]. Authors have suspected that patients with COVID-19 may be more susceptible to pyogenic spinal infections due to immune dys-regulation, immune suppression, or lymphocytopenia [ 11 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

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A 60-Year-Old Man with Gingivitis and Poorly Controlled Diabetes Developing Low Back Pain 1 Week Following Recovery from COVID-19 Diagnosed with Spinal Abscess Due to Streptococcus oralis

Chu¹,

Trager

Chen³

et al. 2022

Am J Case Rep

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Patient: Male, 60-year-old Final Diagnosis: Pyogenic spinal infection Symptoms: Low back pain • neck pain Medication: — Clinical Procedure: Fine needle biopsy • magnetic resonance imaging Specialty: Infectious Diseases • Rehabilitation Objective: Rare disease Background: Streptococcus oralis ( S. oralis ) is a gram-positive bacterium and component of the oral microbiota that can rarely cause opportunistic infection in the immunosuppressed. This report presents a 60-year-old man from Hong Kong with gingivitis and poorly controlled diabetes who visited his chiropractor with low back pain 2 weeks following mild COVID-19 and was diagnosed with paraspinal, psoas, and epidural abscess due to S. oralis . Case Report: The patient tested positive for COVID-19 when asymptomatic, then had a mild 10-day course of the illness, followed by low back pain 1 week later, prompting him to visit his primary care provider, who diagnosed sciatica and treated him with opioid analgesics. He presented to a chiropractor the following week, noting severe low back pain with radiation into the gluteal regions and posterior thighs, difficulty with ambulation, and mild neck pain. Considering the patient’s diabetes, widespread symptoms, and weakness, the chiropractor ordered whole-spine magnetic resonance imaging, which suggested possible multifocal spinal abscess and referred him urgently to a spine surgeon. The surgeon conducted testing consistent with bacterial infection, and referred to an infectious disease specialist, who confirmed S. oralis spinal infection via lumbar paraspinal needle biopsy and culture. The patient was first treated with oral antibiotics, then intravenous antibiotics in a hospital. Over 4 weeks, his spinal pain improved, and laboratory markers of infection normalized. Conclusions: This case illustrates an opportunistic pyogenic spinal infection including paraspinal, psoas, and epidural abscesses caused by S. oralis in an immunocompromised patient following COVID-19 illness.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

A 60-Year-Old Man with Gingivitis and Poorly Controlled Diabetes Developing Low Back Pain 1 Week Following Recovery from COVID-19 Diagnosed with Spinal Abscess Due to Streptococcus oralis

Chu¹,

Trager

Chen³

et al. 2022

Am J Case Rep

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“…Of these, 13 patients had clinical data available. 47 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 …”

Section: Kidney Pathology Potentially Related To Covid-19mentioning

confidence: 99%

COVID-19 and Glomerular Diseases

Klomjit¹,

Zand²,

Cornell³

et al. 2023

Kidney International Reports

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“…This case of IgA nephropathy was cured with methylprednisolone. Some reasons for these simultaneous events are prolonged lymphopenia, endothelial dysfunction, expression of ACE2 receptors in body organs, susceptibility to thrombosis and immune system dysregulation induced by COVID-19 infection (8).…”

Section: Cases Of Iga Nephropathy Following Covid-19mentioning

confidence: 99%

Relapses or de-novo IgA nephropathy following COVID-19 vaccination; a narrative review

et al. 2023

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Immunoglobulin A (IgA) nephropathy is the most common type of glomerulonephritis worldwide characterized by excessive serum levels of glycosylated which triggers the generation of glycan-specific IgG and IgA autoantibodies. This pathological condition results in the formation of circulatory IgA immune complexes, which are essential for the development of glomerular inflammation, especially IgA nephropathy. The serum galactosylated IgA1, IgG, and IgA autoantibodies are suggested as the biomarkers of IgA nephropathy since IgA antibodies are early markers for disease activity too. Serum IgA antibodies emerged as the early COVID-19-specific antibody response about two days after initial symptoms of COVID-19 in comparison with IgG and IgM antibody concentrations, which appeared after five days. IgA nephropathy is frequently presented as microscopic or macroscopic hematuria and proteinuria with a male predominance. COVID-19 infection can include several organs aside from the lungs, such as kidneys through different mechanisms. It is demonstrated in most cases that short-lasting symptoms such as gross hematuria resolve either spontaneously or following a short course of steroids. This review summarized the reported cases of relapses or de-novo reported cases of relapses or de-novo IgA nephropathy and IgA vasculitis following COVID-19 vaccination.

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IgA Nephropathy and Spinal Epidural Abscess After COVID-19 Infection: A Case Report

Cited by 8 publications

References 21 publications

A 60-Year-Old Man with Gingivitis and Poorly Controlled Diabetes Developing Low Back Pain 1 Week Following Recovery from COVID-19 Diagnosed with Spinal Abscess Due to Streptococcus oralis

A 60-Year-Old Man with Gingivitis and Poorly Controlled Diabetes Developing Low Back Pain 1 Week Following Recovery from COVID-19 Diagnosed with Spinal Abscess Due to Streptococcus oralis

COVID-19 and Glomerular Diseases

Relapses or de-novo IgA nephropathy following COVID-19 vaccination; a narrative review

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