IgA nephropathy and infections

Rollino, Cristiana; Vischini, Gisella; Coppo, Rosanna

doi:10.1007/s40620-016-0265-x

Cited by 77 publications

(73 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Approximately 30–40% of IgAN patients progress to end-stage kidney disease within 20 years [1, 2]; however, there is no specific disease-targeted treatment for IgAN [4] because the precise pathogenesis of the disease remains unclear. IgAN patients often manifest macroscopic haematuria in upper respiratory infections such as tonsillitis [5], and some bacterial species have been reported as candidates for the antigen in the pathogenesis of IgAN [6-10]. In fact, Haemophilus parainfluenzae antigen and Staphylococcus aureus cell envelope antigens have been detected in the renal tissue of IgAN patients [6, 9], which led us to the conclusion that infection could be involved in the pathogenesis of IgAN.…”

Section: Introductionmentioning

confidence: 99%

Campylobacter rectus in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients

Misaki

Naka

Wato

et al. 2018

Nephron

View full text Add to dashboard Cite

Background: Periodontitis-related pathogens, such as Campylobacter or Treponema species, have recently been shown to be associated with immunoglobulin A nephropathy (IgAN). Some strains of Streptococcus mutans, a major pathogen of dental caries, harbour the cnm gene that encodes a collagen-binding protein (Cnm). This has also been demonstrated to be associated with urinary protein levels in IgAN patients. Objectives: The purpose of the present study was to analyse the association of IgAN with C. rectus, Treponema denticola and cnm-positive S. mutans in the oral cavity of humans. Methods: The presence of C. rectus, T. denticola and cnm-positive S. mutans strains in saliva samples of 117 IgAN patients and 56 healthy controls was evaluated by PCR, and the subjects’ clinical parameters were analysed. Results: C. rectus was significantly more prevalent in the IgAN group than in the control group (p < 0.05). The C. rectus-positive group was significantly associated with proteinuria in the IgAN group (p < 0.05). In addition, the C. rectus-positive and cnm-positive S. mutans group was shown to be more closely associated with urinary protein levels than the other groups (p < 0.0083). Conclusion: Our results suggest that harbouring C. rectus in the oral cavity could be associated with proteinuria in IgAN patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Campylobacter rectus in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients

Misaki

Naka

Wato

et al. 2018

Nephron

View full text Add to dashboard Cite

show abstract

“…1 IgA deposition is also documented in patients with various comorbidities, ranging from IgA vasculitis, cirrhosis, and autoimmune diseases to chronic infections and neoplasms, which suggest secondary IgAN. [2][3][4][5][6][7] Among them, IgA vasculitis and chronic liver disease are the leading causes of secondary IgAN. 8 IgAN has been found in 9% to 25% of patients who have undergone biopsy at the time of liver transplantation.…”

mentioning

confidence: 99%

Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy

Wang

Xue

et al. 2020

Kidney International Reports

View full text Add to dashboard Cite

Introduction: Galactose-deficient IgA1 (Gd-IgA1) and related IgA/IgG immune complexes have been identified as the key drivers in the pathogenesis of IgA nephropathy (IgAN). However, their roles in the development of secondary IgAN are still unknown. Methods: In this study, we measured the plasma Gd-IgA1 level, IgA/IgG complex, and Gd-IgA1 glomerular deposits in 100 patients with various kinds of secondary IgAN. Plasma Gd-IgA1 was measured using a lectin-based enzyme-linked immunosorbent assay, and Gd-IgA1 in glomerular deposits was examined by double immunofluorescent staining using its specific monoclonal antibody KM55. Results: Patients with secondary IgAN presented with higher plasma Gd-IgA1 levels compared to healthy controls (median, 354.61 U/ml; interquartile range [IQR], 323.93, 395.57 U/ml vs. median, 303.17 U/ml; IQR, 282.24, 337.92 U/ml, P < 0.001) or patients with other kidney diseases (median, 314.61 U/ml; IQR, 278.97, 343.55 U/ml, P < 0.001). A similar trend was observed in plasma IgA/IgG immune complexes or IgA1. There were no differences between secondary and primary IgAN in plasma Gd-IgA1 levels (median, 378.54

show abstract

“…IgAN patients often manifest deterioration of macroscopic haematuria in upper respiratory infections such as tonsillitis3. Some bacteria have been reported as the source of initiating antigens or involved in the pathogenesis of IgAN56789, and Haemophilus parainfluenzae antigen and Staphylococcus aureus cell envelope antigens have been detected in renal tissue of IgAN patients58. In addition, periodontitis-related bacteria were also suggested to be associated with IgAN10.…”

mentioning

confidence: 99%

Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions

Misaki

Naka

Hatakeyama

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of several systemic diseases. In this study, we analysed S. mutans strains isolated from the oral cavity of immunoglobulin (Ig)A nephropathy (IgAN) patients to determine potential relationships between cnm and caries status as well as IgAN conditions. Saliva specimens were collected from 109 IgAN patients and the cnm status of isolated S. mutans strains was determined using PCR. In addition, the dental caries status (decayed, missing or filled teeth [DMFT] index) in patients who agreed to dental consultation (n = 49) was evaluated. The DMFT index and urinary protein levels in the cnm-positive group were significantly higher than those in the cnm-negative group (p < 0.05). Moreover, the urinary protein levels in the high DMFT (≥15) group were significantly higher than those in the low DMFT (<15) group (p < 0.05). Our results show that isolation of cnm-positive S. mutans strains from the oral cavity may be associated with urinary protein levels in IgAN patients, especially those with a high dental caries status.

show abstract

IgA nephropathy and infections

Cited by 77 publications

References 34 publications

<b><i>Campylobacter rectus</i></b> in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients

<b><i>Campylobacter rectus</i></b> in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients

Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy

Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions

Contact Info

Product

Resources

About