IgA mesangial nephropathy and autoimmune haemolytic anaemia associated with linear IgA bullous dermatosis

Linear IgA Disease of Childhood Developing IgA Nephropathy

“…Their conclusion that “This association may not be fortuitous as both conditions are mediated by IgA subclass IgA1, and IgA1 is found in both polymeric and monomeric forms. The lack of previous reports of this association may be due to the fact that IgA mesangial nephropathy is often asymptomatic” (1) may very well be operative in our case.…”

“…The report by van Joost et al (3) of two patients combining skin bullous diseases (bullous pemphigoid and linear IgA bullous disease) with immuno‐complex glomerulonephritis seems to be in the same group. Pena‐Penabad et al (1) referred their experience with a 31‐year‐old woman presenting IgA bullous dermatosis and IgA nephropathy, who also had autoimmune hemolytic anemia. At the same time they extensively reviewed data of malignancies and autoimmune disorders, which may present associated with the skin condition (none of which was recognized in the present case).…”

“…Although IgA nephropathy and linear IgA disease of childhood appear to be mediated by IgA, the presentation of both conditions in the same patient seems to be a very unusual situation. We were able to find just one report referring such a combination (1), although a few other examples might also represent this mixture. We describe a further example occurring in a pediatric patient who initially presented the cutaneous condition.…”

Concurrent Linear Immunoglobulin A Dermatosis, Hashimoto Thyroiditis, and Immunoglobulin A Nephropathy in an Adult

“…Its pathogenesis is unclear, but associations with malignancies, drugs, and inflammatory diseases, notably ulcerative colitis, have been reported in adults1. Several cases of LAD with IgA nephropathy have been reported in children1, but a few in adults2.…”

“…IgA in the mesangium is typically of the polymeric IgA1 subclass. Pena-Penabad et al2 suggested a possible role of the IgA1 subclass in the shared pathogenesis between LAD and IgA nephropathy. Furthermore, in a genome-wide association study of IgA nephropathy, six new genome-wide significant associations were found, most of which were associated with the risk of inflammatory bowel disease5.…”