IgA IMMUNE COMPLEXES IN HENOCH-SCHÖNLEIN PURPURA

Levinsky, R J; Barratt, T. M.

doi:10.1016/s0140-6736(79)92505-4

Cited by 203 publications

(94 citation statements)

References 8 publications

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“…Such complexes can be detected in persons without apparent renal disease, includ-ing healthy individuals and patients with Henoch-Schoenlein purpura without nephritis. 19,24,25 The complexes in patients with HenochSchoenlein purpura without nephritis consist of IgA, but not IgG, and are of smaller mass than the complexes found in patients with IgAN. As these persons do not develop overt renal disease, it can be assumed that these IgA complexes are not nephritogenic.…”

Section: Hit 3: Formation Of Pathogenic Iga1-containing Immune Complexesmentioning

confidence: 99%

“…In contrast, patients with Henoch-Schoenlein purpura with nephritis have larger circulating immune complexes containing IgA and IgG. 24 By analogy with other human diseases caused by immune complexes, it is likely that, in IgAN, the molecular proportion of antigens (galactose-deficient IgA1) and antibodies (IgG or IgA1) determines the size of the formed immune complexes and, consequently, their rate of removal from the circulation, as well as biologic activity. The pathogenic circulating IgA1-IgG immune complexes in patients with IgAN are relatively large (Ͼ800 kD) and thus may be excluded from entry into the hepatic space of Disse to reach the asialoglycoprotein receptor (ASGP-R) on hepatocytes, the normal catabolic pathway for circulatory IgA1.…”

Section: Hit 3: Formation Of Pathogenic Iga1-containing Immune Complexesmentioning

confidence: 99%

See 1 more Smart Citation

The Pathophysiology of IgA Nephropathy

Suzuki

Kiryluk

Novák

et al. 2011

Journal of the American Society of Nephrology

646

577

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Section: Hit 3: Formation Of Pathogenic Iga1-containing Immune Complexesmentioning

confidence: 99%

Section: Hit 3: Formation Of Pathogenic Iga1-containing Immune Complexesmentioning

confidence: 99%

The Pathophysiology of IgA Nephropathy

Suzuki

Kiryluk

Novák

et al. 2011

Journal of the American Society of Nephrology

646

577

View full text Add to dashboard Cite

“…Coppo et al also reported elevated serum levels of IgA and IgA -containing immune complexes in patients with HSPN 20) . In addition, it was reported that all HSP patients have IgA1 -containing circulating immune complexes of small molecular mass, but only those with nephritis have additional IgA1 -IgGcontaining circulating immune complexes of largemolecular -mass 21) . Furthermore, using GalNAcspecific lectin from Helix aspersa, Lau et al reported that the serum levels of galactosedeficient IgA1 (Gd -IgA1) were higher in children with HSPN than in healthy controls and patients with C1q nephropathy 22) .…”

Section: Pathogenesismentioning

confidence: 99%

HENOCH-SCH^|^Ouml;NLEIN PURPURA NEPHRITIS IN CHILDHOOD: PATHOGENESIS, PROGNOSTIC FACTORS AND TREATMENT

Kawasaki

Ono

Ohara

et al. 2013

FJMS

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: Henoch -Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and the deposition of IgA immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. Thus, it is important to clarify the onset mechanism as well as the prognostic factors of Henoch -Schönlein purpura nephritis (HSPN) and to identify the most appropriate treatment. We herein review the pathogenesis, the prognostic factors and treatment of HSPN. As to the pathogenesis, several studies suggest that galactose -deficient IgA1 (Gd -IgA1) is recognized by anti -glycan antibodies, leading to the formation of circulating immune complexes and their mesangial deposition, thereby inducing renal injury. With regard to the prognostic factors, a number of factors have been suggested including nephrotic syndrome, decreased factor XIII activity, hypertension, severe renal injury, high renal accumulation of activated macrophage, alpha -smooth muscle actin, and high serum myeloid -related protein levels. For the treatment of severe HSPN, aggressive therapies including multiple drug combination therapy and plasmapheresis have been shown to be effective in ameliorating proteinuria and histological severity. Nevertheless, detailed investigation into the pathogenesis of HSPN and double -blind randomized control studies on children with HSPN are still necessary.

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“…pero tambien se ha descrito este sindrome en pacientes con deficit selective de Ig A serica 8 . El aumento de los complejos inmunes Ig A estan'a presente casi siempre en el sindrome, sin embargo la presencia de complejos inmunes Ig G se ha relacionado con dano renal 9 . Otono y primavera fueron los meses de mayor incidencia en nuestra casuistica, lo que contrasts con lo descrito en la literatura nacional en que fue mas frecuente en los meses de primavera e invierno l °.…”

Section: Discusionunclassified

Síndrome de Schonlein-Henoch

B¹,

K²,

L³

et al. 1987

Rev. chil. pediatr.

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We re -jrt 47 patients with Schonlein-Henoch syndrome seen by us in the last 5 years. The diagnosis was made on clinicals grounds. The group's means age was 8 years. Sex rates were identical. In 60%of the patients the onset of the syndrome occurred at spring and fall months and also in 60% there were the antecedents that suggested a precedent infectious disease. The mean duration of the clinical manifestation was 14 days (7 to 28 days). Abdominal and articular symptoms occurred in 60% and 40% of the patients respectively and preceded the cutaneous manifestations in 40%of the cases. Evidence of renal compromise was observed in 19%of the cases, but no patients showed deterioration of their renal function during follow-up. Muscular manifestations occurred in 3 patients and one case showed neurological symptoms. Oral steroids were effective in the treatment of severe abdominal pain and were given for no less than seven days. (Keywords: Schonlein-Henoch syndrome, symptoms, signs, laboratory abnormalities).EJ smdrome de Schonlein-Henoch (S. S-H) es una enfermedad multisistemica caracterizada por vasculitis leucocitoclastica 1 -2 con expresion cutanea, articular, gastrointestinal y renal. En ocasiones el diagnostico es dificil y cuando existe compromise abdominal puede simular enfermedades abdominales de tratamiento quirurgico. Con el fin de reconocer las complicaciones y su manejo se analizan los casos de S. S-Hingresados al servicio en los ultimos 5 afios. MATERIAL Y METODOSS; estudiaron 47 pacientes que ingresan al servicio de pediatria del hospital Sotero del Ri'o de Santiago, entre los meses de enero 1980 y marzo 1985, con diagnostico de S. S-H realizado en bases clfnicas, considerando las lesiones cutaneas maculo-papulares en las extremidades inferiores corno elemcntos esenciales. Se registro edad, sexo, epoca del ano, factores desencadenantes, forma de presentation, complicaciones y tratamiento. En todos los pacientes se realize hemograma con recuento de plaquetas, velocidad (horaria) de sedimentation globular, examen de orina completo; en algunos se midio concentration de C^ e Ig A en el suero. Solo se incluye- RESULTADOSVeinticuatro pacientes eran varones. La edad promedio en el momento del diagnostico era 8 anos (rango 3 a 15 anos). La enfermedad ocurrio preferentemente en los meses de otono (36%) y primavera (26%).En 63% de los pacientes exist fan antecedentes morbidos recicntes, sintomas respiratorios (38%); faringoamigdalitis (13%); fiebre tifoidea (4%); estomatitis herpetica (2%), sinusitis (2%) y picadura de insecto (2%); no exist/an antecedentes en 37%. Todos los pacientes tuvieron lesiones cutaneas, siendo estas el requisito fundamental para el diagnostico. Sintomas abdominales se registraron en 30 pacientes (64%), articulares en 20 (43%), renales en 9 (19%), musculares en 3 (6%) y neurologicos en 1 (2%). La duracion de las manifestaciones clinicas fue, en promedio, 14 dias (rango 7 a 28 di'as). Las lesiones cutaneas (47/47 pacientes) consistieron en maculo-papulas confluentes, dolorosas al tacto. La...

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IgA IMMUNE COMPLEXES IN HENOCH-SCHÖNLEIN PURPURA

Cited by 203 publications

References 8 publications

The Pathophysiology of IgA Nephropathy

The Pathophysiology of IgA Nephropathy

HENOCH-SCH^|^Ouml;NLEIN PURPURA NEPHRITIS IN CHILDHOOD: PATHOGENESIS, PROGNOSTIC FACTORS AND TREATMENT

Síndrome de Schonlein-Henoch

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