IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA Nephropathy

Novák, Jan; Julian, Bruce A.; Tomana, Milan; Městecký, Jiří

doi:10.1016/j.semnephrol.2007.10.009

Cited by 175 publications

(144 citation statements)

References 91 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…glycosylated IgA1. 12,16,17,23 Because Gd-IgA1 is present in serum samples of normal individuals, albeit in lower concentrations, the difference in patients with IgAN is consistent with an autoimmune mechanism of disease, with the aberrantly glycosylated IgA1 as autoantigen and glycan-specific IgG or IgA as autoantibodies.…”

Section: Discussionmentioning

confidence: 92%

Autoantibodies Targeting Galactose-Deficient IgA1 Associate with Progression of IgA Nephropathy

Berthoux

Suzuki

Thibaudin

et al. 2012

Journal of the American Society of Nephrology

Self Cite

213

149

View full text Add to dashboard Cite

Mesangial and circulating IgA1 with aberrantly glycosylated hinge region O-glycans characterize IgA nephropathy (IgAN). Unlike healthy individuals, some IgA1 is galactose deficient in patients with IgAN, leaving terminal N-acetylgalactosamine residues in the hinge region exposed. Circulating autoantibodies that recognize such galactose-deficient IgA1 as an autoantigen, or the levels of the autoantigen itself, may allow prediction of disease progression. Here, we analyzed serum samples obtained at diagnosis for autoantigen and autoantibodies from 97 patients with IgAN selected from our prospective cohort according to their absolute renal risk for progression to dialysis or death (0, very low; 1, low; 2, high; 3, very high). We also analyzed samples from controls comprising 30 healthy volunteers and 30 patients with non-IgAN disease. The mean follow-up was 13.8 years. We found that mean serum levels of total autoantigen, normalized IgG autoantibody, and total IgA autoantibody were significantly higher in patients than in the combined controls (all P#0.01). Furthermore, increasing levels correlated with worse clinical outcomes. In Cox regression and Kaplan-Meier analyses, IgG autoantibody levels $1.33 predicted dialysis or death (both P#0.01). In conclusion, these data suggest that serum levels of IgG and IgA autoantibodies strongly associate with the progression of IgAN nephropathy.

show abstract

Section: Discussionmentioning

confidence: 92%

Autoantibodies Targeting Galactose-Deficient IgA1 Associate with Progression of IgA Nephropathy

Berthoux

Suzuki

Thibaudin

et al. 2012

Journal of the American Society of Nephrology

Self Cite

213

149

View full text Add to dashboard Cite

show abstract

“…In view of a clinical application, the IgA2 isotype has other potential advantages. First, IgA1 antibodies contain an elongated heavily O-glycosylated hinge region (32), which is more susceptible to bacterial proteases than the IgA2 hinge (33). This may cause stability issues in vivo, particularly at bacterially colonized sites.…”

Section: Advantages and Disadvantages Of Iga Iso-and Allotypementioning

confidence: 99%

Characterization of a Mutated IgA2 Antibody of the m(1) Allotype against the Epidermal Growth Factor Receptor for the Recruitment of Monocytes and Macrophages

Lohse

Brunke

Derer

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: IgA constitutes a promising antibody isotype, which requires optimization before immunotherapeutic application. Results: P221R-mutated and wild type IgA2m(1) antibodies were similarly effective in killing tumor cells and in recruiting myeloid effector cells. Conclusion: Improved IgA antibodies constitute promising next generation antibodies for tumor therapy. Significance: These studies support the clinical development of therapeutic IgA antibodies.

show abstract

“…IgA nefropatisinin klinik spektrumu geniş olup, bazı hastalarda glomerül filtrasyon hızında azalma olmazken, bazılarında nefrotik sendrom, hipertansiyon ve son dönem böbrek yetmezliği (SDBY) gelişmektedir. 25 yıllık izlemde %25 kronik böbrek hastalığı bulguları, %25 SDBY gelisir (13)(14)(15).…”

Section: Minör Kriterlerunclassified

Polycythemia Vera Associated with IgA Nephropathy: A Case Report

Yıldırım¹,

Soyaltın²,

Komaç³

et al. 2016

Turk Neph Dial Transpl

View full text Add to dashboard Cite

IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA Nephropathy

Abstract: Circulating immune complexes containing aberrantly glycosylated IgA1 play a pivotal role in the pathogenesis of IgAN.

Cited by 175 publications

References 91 publications

Autoantibodies Targeting Galactose-Deficient IgA1 Associate with Progression of IgA Nephropathy

Autoantibodies Targeting Galactose-Deficient IgA1 Associate with Progression of IgA Nephropathy

Characterization of a Mutated IgA2 Antibody of the m(1) Allotype against the Epidermal Growth Factor Receptor for the Recruitment of Monocytes and Macrophages

Polycythemia Vera Associated with IgA Nephropathy: A Case Report

Contact Info

Product

Resources

About