IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells

Ackerman, William E.; Bulmer, Judith N.; Carter, Anthony Michael; Chaillet, J. Richard; Chamley, Larry; Chen, C. P.; Chuong, Edward B.; Coleman, Stephen J.; Collet, G. P.; Croy, B. Anne; Mestre, Amanda M. de; Dickinson, Hayley; Ducray, Jennifer; Enders, Allen C.; Fogarty, Norah M. E.; Gauster, Martin; Golos, Thaddeus G.; Haider, Sandra; Heazell, Alexander E P; Holland, Olivia J.; Huppertz, Berthold; Husebekk, Anne; Roshan, John; Johnsen, Guro M.; Jones, Carolyn J.P.; Kalionis, Bill; König, Julia; Lorenzon-Ojea, Aline R.; Moffett, Ashley; Mello, Joana Carvalho Moreira de; Nuzzo, Anna Maria; Parham, Peter; Parolini, Ornella; Petroff, Margaret G.; Pidoux, Guillaume; Ramírez‐Pinilla, Martha Patricia; Robinson, Wendy P.; Rolfo, Alessandro; Sadovsky, Yoel; Soma, Hiroaki; Southcombe, Jennifer H.; Tilburgs, Tamara; Lash, Gendie E.

doi:10.1016/j.placenta.2011.11.022

Cited by 6 publications

(2 citation statements)

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“…Nos últimos anos, a detecção de diversas proteínas relacionadas à placentação de mamíferos foi reportada nas células epiteliais colunares (CARTER et al, 2007); no epitélio coriônico (ACKERMAN et al, 2012) e em células endoteliais do saco vitelino de placentas de tubarões martelo Sphyrna lewini e S. zygaena (LINNAEUS, 1758) (SOMA et al, 2013. Entre estas proteínas se destaca a proteína específica da gestação PSG1 (Pregnancy-Specific Glycoprotein, PSG1).…”

Section: Tolerância Materno-fetal Em Tubarõesunclassified

Estrutura da placenta epiteliocorial em tubarões e sua interação materno-fetal

Conrado¹,

Bruno²,

Salmon³

et al. 2020

Rev. Educ. Cont. Med. Vet. Zootec.

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Em mamíferos, a nutrição intrauterina de embriões ocorre através da placenta. Porém, em tubarões vivíparos placentários da ordem Carcharhiniformes (famílias Leptochariidae, Triakidae, Hemigaleidae e Carcharhinidae), a nutrição de embriões pode ocorrer de três formas: lecitotrofia (vitelo); histotrofia (secreções uterinas) e placentotrofia. Nesta revisão, é discutida a similitude anatômica, fisiológica e, principalmente imunológica, entre as placentas de tubarões e de mamíferos, mostrando que a tolerância materno-fetal em tubarões placentários e mamíferos é dependente de proteínas como a indoleamina 2,3 – dioxigenase, interleucina-1 e proteínas específicas da gestação.

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Section: Tolerância Materno-fetal Em Tubarõesunclassified

Estrutura da placenta epiteliocorial em tubarões e sua interação materno-fetal

Conrado¹,

Bruno²,

Salmon³

et al. 2020

Rev. Educ. Cont. Med. Vet. Zootec.

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“…We tested the hypothesis that DEX treatment at mid-gestation would reduce branching morphogenesis and hence development of the labyrinth region of the placenta, as this region of the spiny mouse placenta undergoes considerable growth and development at this time [24]. We investigated expression of the bone morphogenic protein 4 (BMP4), transforming growth factor beta 1 (TGFB1), gremlin (GREM1), and wingless-type MMTV integration site family member 4 (WNT4) genes, all of which have been implicated in branching morphogenesis [25][26][27][28] and placentation [29][30][31][32], and for which expression is known to be affected by high levels of glucocorticoid [12,33,34].…”

Section: Introductionmentioning

confidence: 99%

Synthetic Glucocorticoid Dexamethasone Inhibits Branching Morphogenesis in the Spiny Mouse Placenta1

O'Connell

Moritz

Walker

et al. 2013

Biology of Reproduction

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High levels of maternal glucocorticoids during pregnancy can alter the developmental trajectory of some fetal organs. These perturbations are often more profound for the male fetus and have been attributed to passage of glucocorticoids through the placenta. However, the effect of excess glucocorticoids on the placenta itself is less well understood and, particularly, whether this is affected by fetal sex. Expression of genes involved in placental patterning, apoptosis, and nutrient transfer, along with their response to maternal administration of dexamethasone (DEX), has previously been shown to be dependent on fetal sex in the spiny mouse. Here we describe the placental spatiotemporal expression of genes important for branching morphogenesis (WNT4, BMP4, GREM1, TGFB1, KDR, VEGFA). Furthermore, we report that compared to TGFB1 expression in the female labyrinth, expression of TGFB1 in the male labyrinth was higher, and earlier peaks in expression levels of VEGFA Administration of DEX to pregnant dams for 60 h commencing at mid-gestation caused significantly different, sex-related changes in expression of genes that were constitutively different before DEX treatment (e.g., KDR, TGFB1) and those that were not (i.e., VEGFA, WNT4). Similarly, some genes which displayed similar expression profiles across gestation for both sexes also showed similar responses to DEX (e.g., BMP4), while others did not (i.e., GREM1). These results showed that constitutive and glucocorticoid-induced changes in expression of genes involved in branching morphogenesis may be influenced by fetal/placental sex and that fundamental differences exist between a male and female placenta.developmental origins of health and disease,

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Plazentaforschung

Jeschke

2013

Gynäkologe

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IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells

Cited by 6 publications

References 0 publications

Estrutura da placenta epiteliocorial em tubarões e sua interação materno-fetal

Estrutura da placenta epiteliocorial em tubarões e sua interação materno-fetal

Synthetic Glucocorticoid Dexamethasone Inhibits Branching Morphogenesis in the Spiny Mouse Placenta1

Plazentaforschung

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