IFPA Meeting 2011 workshop report II: Angiogenic signaling and regulation of fetal endothelial function; placental and fetal circulation and growth; spiral artery remodeling

Bulmer, Judith N.; Burton, Graham J.; Collins, Sally; Cotechini, Tiziana; Crocker, Ian; Croy, B. Anne; Cvitic, Silvija; Desforges, Michelle; Deshpande, Ruta; Gasperowicz, Malgorzata; Groten, T; Haugen, Guttorm; Hiden, Ursula; Host, Amanda; Jirkovská, Marie; Kiserud, Torvid; König, Julia; Leach, Lopa; Murthi, Padma; Pijnenborg, Robert; Садекова, О.Н.; Salafia, C.M.; Schlabritz‐Loutsevitch, Natalia; Stanek, Jerzy; Wallace, Alison E.; Westermeier, Francisco; Zhang, J.; Lash, Gendie E.

doi:10.1016/j.placenta.2011.11.014

Cited by 13 publications

(4 citation statements)

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“…The recent impact on fetuses is an increasing risk of perinatal death, FGR, small for gestational age fetus, and preterm birth [ 31 , 32 ]. Current studies suggest that placenta dysfunctions have a profound impact on fetal long-term health, such as cardiovascular diseases, hypertension, obesity, nervous system dysfunctions, and psychological behavior abnormalities [ 33 , 34 ]. In this study, we mainly focused on the near-term influences on fetal health.…”

Section: Discussionmentioning

confidence: 99%

Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion

Yang

Wang

et al. 2017

BioMed Research International

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Although a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of subsequent pregnancy outcome is not clearly elucidated. Here, a retrospective analysis was performed on the clinical data of 492 singleton pregnant women. 164 of them with the history of FRSA were enrolled in study group, compared to 328 deliveries without the history of FRSA. For maternal outcomes, patients in the study group delivered earlier with mean gestational age and the incidences of cesarean section and postpartum hemorrhage were higher compared to the control group. For placental outcomes, the incidence of placenta-mediated pregnancy complications (PMPC) in the study group increased in terms of late-onset preeclampsia, oligohydramnios, early-onset fetal growth restriction, and second-trimester abortion. Patients in the study group were more likely to suffer from placenta accreta, placenta increta, and placenta percreta. For perinatal outcomes, the proportion of birth defects of newborns in the study group was greater. At last, logistic regression analyses showed that the history of FRSA was an independent risk factor for cesarean section and pregnancy complications. In conclusion, women with the history of FRSA are often exposed to an elevated incidence of maternal-placental-perinatal adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion

Yang

Wang

et al. 2017

BioMed Research International

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“…HTR8/SVneo cells show an expression profile that is just the opposite [12, 31]. In this aspect, it is interesting that HTR8/SVneo cells express N-cadherin, while their JEG3 counterparts do not [34], meaning that HTR8/SVneo express at least two known epithelial-mesenchymal transition (EMT) markers (N-cadherin and vimentin), which is also a sign of partial dedifferentiation (reviewed in [27]). Finally, HTR8/SVneo cells express HLA-G, a typical extravillous trophoblast differentiation marker [33], only weakly or not at all [12] and secrete β -HCG, a hallmark characteristic of a syncytiotrophoblast cell (as reviewed in [35]), weakly, but more than primary cytotrophoblast, which do not secrete hCG at all [9].…”

Section: Discussionmentioning

confidence: 99%

HTR8/SVneo Cells Display Trophoblast Progenitor Cell-Like Characteristics Indicative of Self-Renewal, Repopulation Activity, and Expression of “Stemness-” Associated Transcription Factors

Weber

Knoefler²,

Schleußner³

et al. 2013

BioMed Research International

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Introduction. JEG3 is a choriocarcinoma—and HTR8/SVneo a transformed extravillous trophoblast—cell line often used to model the physiologically invasive extravillous trophoblast. Past studies suggest that these cell lines possess some stem or progenitor cell characteristics. Aim was to study whether these cells fulfill minimum criteria used to identify stem-like (progenitor) cells. In summary, we found that the expression profile of HTR8/SVneo (CDX2+, NOTCH1+, SOX2+, NANOG+, and OCT-) is distinct from JEG3 (CDX2+ and NOTCH1+) as seen only in human-serum blocked immunocytochemistry. This correlates with HTR8/SVneo's self-renewal capacities, as made visible via spheroid formation and multi-passagability in hanging drops protocols paralleling those used to maintain embryoid bodies. JEG3 displayed only low propensity to form and reform spheroids. HTR8/SVneo spheroids migrated to cover and seemingly repopulate human chorionic villi during confrontation cultures with placental explants in hanging drops. We conclude that HTR8/SVneo spheroid cells possess progenitor cell traits that are probably attained through corruption of “stemness-” associated transcription factor networks. Furthermore, trophoblastic cells are highly prone to unspecific binding, which is resistant to conventional blocking methods, but which can be alleviated through blockage with human serum.

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“…Primary human umbilical vein endothelial cells were isolated by enzymatic digestion as previously described (23) and used as an in vitro model to determine the effect of glucose concentration on the internalization of exosomes.…”

Section: Endothelial Cell Isolationmentioning

confidence: 99%

The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells

Rice

Scholz-Romero

Sweeney

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

142

119

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IFPA Meeting 2011 workshop report II: Angiogenic signaling and regulation of fetal endothelial function; placental and fetal circulation and growth; spiral artery remodeling

Cited by 13 publications

References 0 publications

Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion

Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion

HTR8/SVneo Cells Display Trophoblast Progenitor Cell-Like Characteristics Indicative of Self-Renewal, Repopulation Activity, and Expression of “Stemness-” Associated Transcription Factors

The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells

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