Ifosfamide tolerance in osteosarcoma patients previously treated with cis-Diamminedichloroplatinum-II: Renal, hematologic, and neurologic observations

Canpolat, Cengiz; Pearson, Peggy; Robertson, Resa; Jaffe, Norman

doi:10.1002/(sici)1096-911x(199601)26:1<36::aid-mpo5>3.0.co;2-w

Cited by 10 publications

(17 citation statements)

References 34 publications

(15 reference statements)

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“…These events prompted a review of our past experiences. We noted that 2 of 20 patients previously treated with conventional IFX (9 g/m 2 /course) also developed renal failure; one required a renal transplant 31. Ferrari et al conducted a prospective study in recurrent osteosarcoma patients, who were heavily pretreated with cisplatin and high‐dose methotrexate.…”

Section: Discussionmentioning

confidence: 98%

High‐dose ifosfamide in relapsed pediatric osteosarcoma: Therapeutic effects and renal toxicity

Berrak

Pearson

Berberoĝlu

et al. 2004

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 98%

High‐dose ifosfamide in relapsed pediatric osteosarcoma: Therapeutic effects and renal toxicity

Berrak

Pearson

Berberoĝlu

et al. 2004

Pediatric Blood & Cancer

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“…2,25 Nephrotoxicity (occurring in about 20–30% of patients receiving CP 26 ) is the dose-limiting side effect of CP. 27 Other side effects can include hypomagnesemia (40–100% of patients), 28 Fanconi-like syndrome, distal renal tubular acidosis, hypocalcemia, renal salt wasting, and hyperuricemia. 29 Although the mechanism behind CP-induced nephrotoxicity is not well understood, previous studies suggested that CP interacts with DNA through the formation of covalent adducts between certain DNA bases and the platinum compound, leading to cell cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Effect of rutin on cisplatin-induced damage in human mesangial cells via apoptotic pathway

Zhang

Wang

et al. 2018

Hum Exp Toxicol

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Cisplatin (CP) is one of the most effective and widely used compounds in the treatment of disease, including cancer, but is known to induce toxicity in patients. Rutin (RUT) is a flavonoid glycoside from Sophora japonica L. that has been shown to possess antioxidative, anti-inflammatory, and antiviral properties. RUT is also known to attenuate cardiotoxicity, isoproterenol-induced cardiac fibrosis, and ischemia/reperfusion-associated hemodynamic alteration, and prevents high glucose-induced renal glomerular endothelial hyperpermeability. In this study, we investigated the effect of RUT on CP-induced nephrotoxicity. CP was used to induce toxicity in human mesangial cells (HMCs), HMCs were pretreated with different concentrations of RUT before being exposed to 10 μg/mL of CP. A positive group was pretreated with antioxidant agent N-acetylcysteine prior to CP administration. At doses between 12.5 and 25 μM, RUT prevented CP-induced reduction in cell viability. Treatment with RUT suppressed intracellular reactive oxygen species and malonic dialdehyde levels and inhibited cell apoptosis. RUT reversed the CP-induced upregulation of p53, cleaved-caspase-3, and increased pro-caspase-3 and pro-caspase-9 levels. In conclusion, the RUT can relieve CP-induced nephrotoxicity by inhibiting the p53/caspase signaling pathway.

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“…Delayed elimination of these metabolites, either due to a constitutional enzyme deficiency or in the context of liver or renal failure, could accentuate the risk of neurotoxicity 2. Prior treatment with cisplatin has been shown to increase this risk due to decreased renal clearance 10,23. In our case, no specific risk factor could be identified, suggesting an individual susceptibility.…”

Section: Discussionmentioning

confidence: 65%

Ifosfamide neurotoxicity: An atypical presentation with psychiatric manifestations

Kerdudo

Orbach

Sarradet³

et al. 2005

Pediatric Blood & Cancer

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Ifosfamide can be responsible for acute central neurotoxicity in children and adolescents treated for cancer. The signs of acute encephalopathy most frequently observed are: alteration of consciousness, cerebellar syndrome, asthenia, urinary incontinence, cranial nerve palsy, and seizures. Various combinations of these signs may occur, but disorders of consciousness and drowsiness are common. We describe the case of a young man presenting with reversible acute hypomanic disorder during ifosfamide-based chemotherapy and discuss the possible mechanisms of this toxicity.

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Ifosfamide tolerance in osteosarcoma patients previously treated with cis-Diamminedichloroplatinum-II: Renal, hematologic, and neurologic observations

Cited by 10 publications

References 34 publications

High‐dose ifosfamide in relapsed pediatric osteosarcoma: Therapeutic effects and renal toxicity

High‐dose ifosfamide in relapsed pediatric osteosarcoma: Therapeutic effects and renal toxicity

Effect of rutin on cisplatin-induced damage in human mesangial cells via apoptotic pathway

Ifosfamide neurotoxicity: An atypical presentation with psychiatric manifestations

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