Ifosfamide-induced hyperpigmentation

Periungal hyperpigmentation induced by cisplatin

“…2 Such pigmentation has no correlation with any systemic adverse effects due to chemotherapy, and is thought to be of cosmetic significance only. 3 To the best of our knowledge, cisplatin-induced hyperpigmentation has been previously reported in only two cases by Lamki et al and Jaffe. 4,5 Two patients with osteosarcoma treated with cisplatin developed localized hyperpigmentation, one over the dorsal aspects of the hands and feet, elbows and knees, and operative incision, and the other along the sides of the thorax, juxtaposed to the rubber shoulder pads of the patient's crutches.…”

“…A variety of chemotherapeutic agents may induce discoloration or hyperpigmentation of the skin and nails including: 5‐fluorouracil, busulfan, doxorubicin, cyclophosphamide, methotrexate, bleomycin, actinomycin, and ifosfamide 2 . Such pigmentation has no correlation with any systemic adverse effects due to chemotherapy, and is thought to be of cosmetic significance only 3 …”

Drug-Induced Hyperpigmentation: Review and Case Series

“…This hyperpigmentation may occur after only 1 course or several months of therapy, and has a more unpredictable course than that of cyclophosphamide. 48 Like ifosfamide, thiotepa can cause hyperpigmentation in occluded areas (it is believed to be excreted in sweat, and this may be the mechanism responsible for the hyperpigmentation). 49 Other alkylating agents that cause hyperpigmentation are platinum metals, with cisplatin producing hyperpigmentation in 70% of patients, which may be localized or irregular, and affects the hair, nails, and oral mucosa.…”