Ifosfamide for children with solid tumours

Progressive glomerular toxicity of ifosfamide in children

“…Glomerular histology of I F 0 toxicity is previously unreported in children, though hyalinization of some glomeruli was seen in an adult [18]. Severe tubular atrophy and interstitial nephritis following I F 0 therapy have been reported in an infant [19].…”

Incidence and etiology of ifosfamide nephrotoxicity: Report of a meeting held in Rhodes, Greece, October 3, 1991, sponsored by Asta Medica, Frankfurt, Germany

“…Since this publication, 5 out of a further 62 patients treated with an Ifosfamide, Carboplatin, Etoposide protocol had been identified with Fanconi syndrome, and 13 had evidence of renal tubular acidosis (Dr. Neyssa Marina, personal communication). It seemed likely that cumulative dose and prior exposure to cisplatin are likely to be important risk factors, and further experience with renal biopsy, which had been previously reported in only one other case [9], was encouraged.…”