IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration
Alessandro Cutilli,
Suze A. Jansen,
Francesca Paolucci
et al.
Abstract:The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune responses ranging from anti-to pro-inflammatory depending on the setting. Here, using a 3D co-culture system based on human intestinal epithelial organoids, we explore the capacity of IFNγ-exposure to reprogram intestinal epithelia and thereby directly modulate lymphocyte responses. IFNγ treatment of organoids led to transcriptional reprogramming, marked by a switch to a pro-inflammatory gene expression profile, including trans… Show more
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