IFNT, ISGs, PPARs, RXRs and MUC1 in day 16 embryo and endometrium of repeat-breeder cows, with or without subclinical endometritis

Kasimanickam, R.; Kasimanickam, Vanmathy

doi:10.1016/j.theriogenology.2020.09.001

Cited by 9 publications

(13 citation statements)

References 44 publications

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“…Interferon tau (IFNτ) secreted by bovine embryos supports its elongation and is a signal of maternal recognition of pregnancy (Brooks et al, 2014). Abundance of IFNτ may be influenced by both genetic and environ-mental factors (Brooks et al, 2014;Kasimanickam and Kasimanickam, 2020). The results of previous research are inconclusive and some report differences in IFNτ secretion between embryos produced in vitro with the use of various assisted reproduction techniques, and in vivo (Arnold et al, 2006), while others do not (Yao et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Female Bovine Donor Age Influence on Quality Markers’ Expression and PPARS Abundance in Day 7 Blastocysts

Jaworska

Nowicki²,

Kowalczyk-Zięba

et al. 2023

Annals of Animal Science

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In bovine females, the production of embryos derived from oocytes obtained by ovum pick-up (OPU) is becoming a frequent procedure. Collection of oocytes from pre-pubertal animals enables shortening the genetic distance, especially in high-value animals. Nevertheless, the oocyte and later embryo developmental potential differ between oocytes derived from prepubertal and adult heifers. The aim of this study was to determine the possible underlying causes for differences in quality between embryos obtained from pre-pubertal and pubertal heifers. Cumulus oocyte complexes were collected via OPU. The expression of PLAC8, IFNτ, IGFR1, SOX2, and OCT4 in blastocysts was evaluated. The transcriptome of peroxisome proliferator-activated receptors (PPARs), the major genes involved in the metabolism and development of the embryo, and the embryo quality marker gene expression (PLAC8, IFNτ, IGFR1, SOX2, and OCT4) in the day 7 blastocysts derived from oocytes collected from pre-pubertal or pubertal heifers differed significantly. The expression of genes involved in basic biological processes of early embryonic development differed between embryos derived from oocytes collected from pre-pubertal and pubertal heifers. The obtained data may be used to adjust culture conditions to the biological requirements of the embryos derived from oocytes collected from pre-pubertal heifers, and to predict the possibility of successful development of the embryo.

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Section: Discussionmentioning

confidence: 99%

Female Bovine Donor Age Influence on Quality Markers’ Expression and PPARS Abundance in Day 7 Blastocysts

Jaworska

Nowicki²,

Kowalczyk-Zięba

et al. 2023

Annals of Animal Science

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“…Using gene ontology, it has been determined that interferon-τ-stimulated genes (as ISG15, SLC2A1, SLC27 A6, and CXCL), but also peroxisome proliferator-activated receptors, are involved in coding the trophectoderm cell proliferation and migration and prompted conceptus elongation on day 16 [ 55 ]. The interruption in crosstalk between the endometrium and conceptus may impair conceptus elongation in RBCs with SCE.…”

Section: New Omics and Technologies To Understand The Rbc Syndromementioning

confidence: 99%

Current Insights in the Repeat Breeder Cow Syndrome

Marı́n

Arias

2023

Animals

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Cows can have difficulties becoming pregnant, and in certain cases, these reproductive failures do not have an evident cause. Furthermore, when these failures are repeated three or more times with estrous cycles of normal duration and in the absence of evident clinical signs, it is considered repeat breeder cow (RBC) syndrome. A substantive incidence of RBC syndrome has been reported all over the world, which severely affects the farm economy. This paper reviews those studies particularly focused on RBC syndrome from 2000 to 2023 but also includes consolidated information until this date. Hormonal imbalances, undetectable oviductal or uterine defects, or poor oocyte or embryo quality have been reported as causes of RBC syndrome, while subclinical endometritis has been considered a relevant causal agent. However, it is unresolved why this condition is recurrent in certain animals, despite the implementation of corrective management actions or treatments. Recent studies evaluate the putative role of certain genes, factors, hormones, or proteins in the pathogenesis of RBC syndrome. Numerous risk factors contribute to the appearance of this syndrome, and some of them could be mitigated to partially prevent this infertility, while others cannot be changed. Due to the complexity of this syndrome, it is important to increase knowledge about the mechanisms involved, develop new diagnostic tools to differentiate causal agents, and implement new treatments to restore fertility. There is consensus about the huge repercussions of this syndrome on farm profitability, but further studies are now needed to describe its economic impact.

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“…The developing embryo eventually undergoes a process called conceptus elongation, which is a short-lived phenomenon resulting from remodeling and cellular migration of the developing embryo. Conceptus elongation begins on days 12-13 in ewes and is associated with implantation and recognition of gestation (Kasimanickam & Kasimanickam, 2020). Around day 12, the embryo's trophoectoderm cells begin to secrete IFN, the gestation recognition factor that overrides the uterine luteolytic mechanism to ensure maintenance of a functional CL (Lonergan & Sanchez, 2020).…”

Section: Maternal Recognition Of Gestation and Implantationmentioning

confidence: 99%

Involvement of the Interferon Tau Gene in Maternal Recognition of Gestation in Sheep

Conde-Hinojosa

Gallegos‐Sánchez

Hernández

et al. 2021

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Objective: To describe the involvement of the interferon tau gene in the maternal recognition of pregnancy in sheep. Design/Methodology/Approach: A search and analysis of the scientific documents retrieved from the Web of Science and Scopus databases related to the functions of the interferon tau gene in the maternal recognition of pregnancy in sheep were conducted. Results: The interferon tau gene (IFNτ) participates in maternal recognition of pregnancy to avoid possible rejection of the embryo, and supports the secretion of progesterone involved in preparing the endometrium for implantation; it also inhibits myometrial motility to maintain pregnancy. IFNτ stimulates the transcription of so-called interferon-stimulated genes (ISGs), which are the effectors of cell-autonomous antiviral defense. One of the representative members of ISGs is the interferon 15-stimulated gene (ISG15) which regulates endometrial receptivity at implantation, as well as survival, growth and development of the conceptus. Study Limitations/Implications: Most embryonic losses occur between fertilization and maternal recognition of pregnancy. Understanding this issue is essential to understanding the possible causes of early pregnancy losses. Findings/Conclusions: Considerable progress has been made in the discovery of how the IFNτ and ISG15 genes act in maternal recognition of gestation in sheep

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IFNT, ISGs, PPARs, RXRs and MUC1 in day 16 embryo and endometrium of repeat-breeder cows, with or without subclinical endometritis

Cited by 9 publications

References 44 publications

Female Bovine Donor Age Influence on Quality Markers’ Expression and PPARS Abundance in Day 7 Blastocysts

Female Bovine Donor Age Influence on Quality Markers’ Expression and PPARS Abundance in Day 7 Blastocysts

Current Insights in the Repeat Breeder Cow Syndrome

Involvement of the Interferon Tau Gene in Maternal Recognition of Gestation in Sheep

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