IFNL4 genetic variant can predispose to COVID-19

Jmr, Saponi-Cortes; Rivas,; Jfs, Muñoz-Torrero; Zamorano, Jose

doi:10.1101/2021.03.01.21252696

Cited by 4 publications

(2 citation statements)

References 18 publications

(48 reference statements)

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“…Linkage disequilibrium between rs368234815-TT allele and rs12979860-C allele results in the same frequencies distribution pattern for the latter genetic variant: C allele is present in 89.8-95.2% Chinese genomes, in 69.1% of European genomes and in 33.1% of African genomes (The 1000 Genomes Project Consortium, 2015). Frequency of the rs12979860 C/C genotype in IFNL4 gene was significantly lower in COVID-19 patients (p < 0.001) (Saponi-Cortes et al, 2021).…”

Section: The Ifnl4 Locusmentioning

confidence: 90%

A Role of Variance in Interferon Genes to Disease Severity in COVID-19 Patients

et al. 2021

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The rapid rise and global consequences of the novel coronavirus disease 19 (COVID-19) have again brought the focus of the scientific community on the possible host factors involved in patient response and outcome to exposure to the virus. The disease severity remains highly unpredictable, and individuals with none of the aforementioned risk factors may still develop severe COVID-19. It was shown that genotype-related factors like an ABO Blood Group affect COVID-19 severity, and the risk of infection with SARS-CoV-2 was higher for patients with blood type A and lower for patients with blood type O. Currently it is not clear which specific genes are associated with COVID-19 severity. The comparative analysis of COVID-19 and other viral infections allows us to predict that the variants within the interferon pathway genes may serve as markers of the magnitude of immune response to specific pathogens. In particular, various members of Class III interferons (lambda) are reviewed in detail.

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Section: The Ifnl4 Locusmentioning

confidence: 90%

A Role of Variance in Interferon Genes to Disease Severity in COVID-19 Patients

et al. 2021

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“…Coronavírus que, mesmo não sendo um flavivírus, já se é sabido da participação do IFN-λ no curso e evolução da doença(50,51). Polimorfismos de nucleotídeo único (SNPs) em genes do IFN-λ, têm sido amplamente investigados no contexto das infecções virais.…”

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Febre amarela: pesquisa de polimorfismos do INF- e associação com o desfecho da doença

Ferrara

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Nunca saberemos o quão forte somos até que ser forte seja a única escolha.Assim, venho com muita alegria agradecer primeiramente a Deus por ter me mantido firme e me dado graça mesmo quando as minhas forças não existiam mais.Agradeço ao meu marido que sempre acreditou em mim, me apoiou com amor e empatia, seja emocionalmente ou financeiramente, me incentivando até o final -Sem você isso nunca teria existido! Agradeço aos meus pais por terem me dado a vida e condições para escolher sempre o que eu quisesse fazer.

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IMPACT OF GENETIC ANCESTRY ON THE DISTRIBUTION OF INTERFERON-λ4 RS12979860 POLYMORPHISM IN a GLOBAL POPULATION OF BUENOS AIRES, ARGENTINA

Mansilla

Avena

Dejean

et al. 2022

BAG

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Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have suffered a positive selection pressure throughout the evolutionary history of the genus Homo. An intronic variant within the IFNλ4 locus (rs12979860, T˃C) emerged as one of the main gene determinants of the response to HCV and other viruses. The rs12979860-C allele has a differential frequency in African, European and Native American populations, though South American data are scarce. Here we characterize for the first time the distribution of rs12979860 genotypes in a sample of the global population of Buenos Aires, Argentina, assessing its association with European, Native American and African parental components. The rs12979860 genotypes were determined by PCR-RFLP in DNA samples from donors of a blood banks of Buenos Aires (n=96), whose genetic individual ancestry (European, African or Native American) had been previously determined using molecular markers. The distribution of rs12979860-CC, CT and TT was 29.17%, 50.0% and 20.83%, respectively. A significant increase in the frequency of CC among donors with a strong European contribution and a greater impact of the Native American component among donors carrying the T allele were observed. Native American and European components were associated to the rs12979860 distribution in a sample of the global population of Buenos Aires, while no differences were directly attributable to the African ancestry. Considering interferon´s key role in antiviral responses, our results may contribute to both bioanthropological and immunogenetic studies associated with infectious diseases. Key words: ancestry, Buenos Aires, IFNλ4 polymorphism, rs12979860 distribution.

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IFNL4 genetic variant can predispose to COVID-19

Cited by 4 publications

References 18 publications

A Role of Variance in Interferon Genes to Disease Severity in COVID-19 Patients

A Role of Variance in Interferon Genes to Disease Severity in COVID-19 Patients

Febre amarela: pesquisa de polimorfismos do INF- e associação com o desfecho da doença

IMPACT OF GENETIC ANCESTRY ON THE DISTRIBUTION OF INTERFERON-λ4 RS12979860 POLYMORPHISM IN a GLOBAL POPULATION OF BUENOS AIRES, ARGENTINA

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