IFNL4, ACE1, PKR, IFNG, MBL2 genetic polymorphisms and severe COVID-19

Abstract

Background: Corona virus disease 2019 (COVID-19) is caused by SARS-CoV-2, the pathogenic process of SARS-Cov-2 is related to the angiotensin-2 converting enzyme (ACE-2) on host cells. The genetic polymorphisms among different populations may influence the progression of COVID-19. However, the effects of IFNL4, ACE1, PKR, IFNG, and MBL2 in severe COVID-19 have not been systematically assessed.Methods: We will include all relevant English and Chinese studies by searching the following electronic databases: PubMed, MEDLINE, Embase, Web of Science, Scopus, the Cochrane Library, and Google Scholar before March 31, 2022. Two researchers will independently screen and extract the literature. The methodological quality of the included studies will be evaluated by the Cochrane Handbook for Systematic Reviews of Interventions.Result: This systematic review and meta-analysis will summarize the association of IFNL4, ACE1, PKR, IFNG, MBL2 genetic polymorphisms, and severe COVID-19. The results will be submitted to a peer-reviewed journal once completed. Conclusion:The conclusion of our study will provide evidence for the early prevention of severe COVID-19.

Assessment of the Interferon-Lambda-3 Polymorphism in the Antibody Response to COVID-19 in Older Adults Seropositive for CMV

“…On the other hand, Saponi-Cortes et al [ 69 ] reported that allele 2 (TT), in the IFN-lambda gene (rs12979860), was significantly overexpressed in COVID-19 patients compared to non-COVID-19 controls [ 69 ]. According to the same authors, and with some information previously cited, whereas the T allele has been associated with an ineffective viral clearance, e.g., for HCV and other RNA viruses, the presence of the C allele could favor the clearance of these viruses [ 28 , 29 , 69 , 70 ]. Although it has been emphasized that some genetic polymorphisms, particularly in the IFN-lambda gene, could be involved in susceptibility to COVID-19 [ 71 ], the discrepant results found until now in the literature reinforce the need for further studies focused on improving our understanding of the impact of polymorphism in the IFN-lambda gene in the COVID-19 context.…”