IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis

Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guérin Vaccination of Newborns

“…Current evaluation of vaccine-induced immunity focuses on immunity essential for protection against TB. For example, experimental and clinical evidence support a critical role for CD4 T cells (5,6), particularly IFN-g production by these cells (7,8), in protection against TB. This outcome is, therefore, the most commonly measured when determining vaccine take.…”

Evaluation of IFN-γ polymorphism+874 T/A in patients with recurrent tonsillitis by PCR Real Time Mismatch Amplification Mutation Assay (MAMA Real Time PCR)

“…In 34 cases the results of the two assays were discordant: the ARMS-PCR revealed a nonspecific signal in contrast to the specificity of the MAMA-PCR; as a result, the last one was considered the better assay for the comparison with sequencing, the 'gold standard' technique that reveal 100% of correspondence with MAMA Real Time PCR (data not shown). Different studies in literature showed a relationship between the presence of the allele A and a low response to infectious agents [1][2][3][4] or autoimmune pathologies [9,10]. Different studies on tuberculosis found that individuals whit genotype AA produce significantly lower levels of IFN-c compared to individuals carrying one or two copies of allele T [1,2,25].…”

“…Different studies in literature showed a relationship between the presence of the allele A and a low response to infectious agents [1][2][3][4] or autoimmune pathologies [9,10]. Different studies on tuberculosis found that individuals whit genotype AA produce significantly lower levels of IFN-c compared to individuals carrying one or two copies of allele T [1,2,25]. Our preliminary data suggest that tonsillectomy patients had a statistical trend to possess the low IFN-c polymorphism when compared with control subject (p = 0.3) but is not statistically significant.…”

“…Individuals defective in the genes for IFN-c or IFN-c receptor have been shown to be predisposed to bacterial and viral infections, such as Mycobacterium tuberculosis [1,2], hepatitis B and C virus [3], Parvovirus B19 [4], BK virus [5], Cytomegalovirus [6]; to asthma [7] and severe respiratory syncytial virus infections [8]; to autoimmune disease, including Hashimoto's Thyroiditis and Graves' Disease [9], rheumatoid arthritis [10], systemic lupus erythematosus [11]; to neoplasia such as breast cancer [12].…”

The +874T/A polymorphism in the interferon-γ gene and tuberculosis risk: An update by meta-analysis

“…Second, gene polymorphism can vary substantially between different racial or ethnic populations; this was not analyzed in their study. Third, in the past few years, more studies concerning the IFN-␥ 874T/A polymorphism with TB risk had been published in different populations [3,6,11,12,19,[22][23][24][25]28], and these data should also be included. Thus, we carried out a meta-analysis that included the latest data to investigate in particular the association of IFN-␥ ϩ874T/A polymorphism with TB risk, and to investigate ethnicity-specific TB risk.…”