IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

Blazek, Katrina; Eames, Hayley L.; Weiss, Miriam; Byrne, Adam; Perocheau, Dany; Pease, James E.; Doyle, Sean E.; McCann, Fiona E.; Williams, Richard O.; Udalova, Irina A.

doi:10.1084/jem.20140995

Cited by 191 publications

(226 citation statements)

References 34 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…These results suggest that lower levels of IL-22 in the uterine decidua in patients with unexplained recurrent pregnancy loss may contribute to a disruption of decidual homeostasis and ultimately lead to early pregnancy loss. In relation to IL-28A, it has been reported that the administration of IL-28A completely reverses the development of collagen-induced arthritis in a murine model, supporting also its possible anti-inflammatory function [36] . In this sense, from our results, it can be suggested that IL-20, IL-22, and IL-28A have potential anti-inflammatory and protective effects during pregnancy which could be abrogated at the onset of labor.…”

Section: Discussionmentioning

confidence: 85%

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Reyes-Lagos

Peña-Castillo

Pérez‐Sánchez³

et al. 2017

Neuroimmunomodulation

View full text Add to dashboard Cite

Labor is regarded as increased myometrial activity with a regular contractility pattern. At this final stage of pregnancy, myometrial quiescence is lost, accompanied by altered immune homeostasis. It is well known that the interleukin (IL)-10 family of cytokines modulates immunological responses mainly in epithelial cells, including the endometrium. To investigate their inflammatory profile during labor, we performed a longitudinal study in a group of healthy pregnant women (n = 20) with uncomplicated pregnancies in the third trimester of pregnancy and during active labor. Blood was sampled from pregnant women in the third trimester (gestational age 32-38 weeks, mean 36 ± 2 weeks) and during active labor (39-41 weeks of gestation, mean 40 ± 1 weeks). Serum levels of several cytokines were measured using multiplex immunoassays for both stages, indicating that the concentrations of IL-10, IL-20, IL-22, IL-28A, and interferon (IFN)-γ were significantly decreased during active labor in comparison with third-trimester levels (p < 0.05). Our analysis did not find significant correlations between IL-10, IL-20, IL-22, IL-28A, and IFN-γ levels and gestational age. However, our data suggest that the systemic downregulation of several members of the IL-10 family of cytokines plays an important role in the activation of myometrial smooth cells associated with uterine contractions during active labor. Downregulation of this IL-10 family of cytokines seems to coincide with the well-reported functional progesterone withdrawal during labor. Likewise, lower plasma IFN-γ concentrations may indicate a role for IFN-γ in active labor.

show abstract

Section: Discussionmentioning

confidence: 85%

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Reyes-Lagos

Peña-Castillo

Pérez‐Sánchez³

et al. 2017

Neuroimmunomodulation

View full text Add to dashboard Cite

show abstract

“…Each of these cell types has been shown to express both uPA and uPAR, 19,[44][45][46][47] and each has been linked to arthritis pathogenesis in both RA and CIA. 20,33,[48][49][50][51] Whether uPA/uPAR-dependent mechanisms of arthritis pathogenesis occur through multiple hematopoietic cell types and whether these mechanisms require uPA production by one cell type and uPAR expression by another remain to be determined.…”

Section: Discussionmentioning

confidence: 99%

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Dickensheets and colleagues could not find IFNk induced ISG expression in lymphocytes or monocytes [22], two cell types that are central for regulating anti-HCV immune responses or for exerting antiviral effector mechanisms. More recently, Blazek and colleagues identified neutrophils as IFNk responsive regulators of Th17 and cd T cells in a mouse collagen-induced arthritis model [23]. It remains to be clarified if neutrophils could also be involved in a similar cell-cell network during AHC.…”

Section: Host-virus Interactions In Acute Hepatitis Cmentioning

confidence: 99%

Host – hepatitis C viral interactions: The role of genetics

Heim

Bochud

George

2016

Journal of Hepatology

View full text Add to dashboard Cite

Hepatitis C virus (HCV) is a major cause of chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a minority of patients can clear the virus spontaneously. Elimination of HCV during acute infection correlates with a rapid induction of innate, especially interferon (IFN)-induced genes, and a delayed induction of adaptive immune responses. There is a strong association between genetic variants in the IFNλ (IL28B) locus with the rate of spontaneous clearance. Individuals with the ancestral IFNλ4 allele capable of producing a fully active IFNλ4 are paradoxically not able to clear HCV in the acute phase and develop chronic hepatitis C (CHC) with more than 90% probability. In the chronic phase of HCV infection, the wild-type IFNλ4 genotype is strongly associated with an induction of hundreds of classical type I/type III IFN stimulated genes in hepatocytes. However, the activation of the endogenous IFN system in the liver is ineffective in clearing HCV, and is even associated with impaired therapeutic responses to pegylated (Peg)IFNα containing treatments. While the role of genetic variation in the IFNλ locus to the outcome of CHC treatment has declined, it is clear that variation not only at this locus, but also at other loci, modulate clinically important liver phenotypes, including inflammation, fibrosis progression and the development of hepatocellular cancer. In this review, we summarize current knowledge about the role of genetics in the host response to viral hepatitis and the potential future evolution of knowledge in understanding host-viral interactions.

show abstract

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

Abstract: Blazek et al. demonstrate that treatment with IL-28A reduces inflammation in collagen-induced arthritis by restricting the recruitment of IL-1β+ neutrophils.

Cited by 191 publications

References 34 publications

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells

Host – hepatitis C viral interactions: The role of genetics

Contact Info

Product

Resources

About

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

Abstract: Blazek et al. demonstrate that treatment with IL-28A reduces inflammation in collagen-induced arthritis by restricting the recruitment of IL-1β+ neutrophils.

Cited by 191 publications

References 34 publications

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-&#x03B3; Decrease from the Third Trimester of Pregnancy to Active Labor

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-&#x03B3; Decrease from the Third Trimester of Pregnancy to Active Labor

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells

Host – hepatitis C viral interactions: The role of genetics

Contact Info

Product

Resources

About

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor