IFN-γ Promotes, but Dexamethasone Dissociates, Toll-Like Receptor 2/1-Induced Host Responses in Human Macrophages

Kröll, Philipp; Knoke, Kristin; Steiger, Julia; Fabri, Mario

doi:10.1016/j.jid.2018.07.035

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Tlr Expression and Function At Mucosal Surfaces1

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2021

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References 15 publications

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“…Macrophages and DC that make these IFN-gamma-inducing factors are known as M1 and DC1, respectively. In the context of an infection, IFN-gamma stimulates macrophage activity, including increase in TLR expression and activity [ 64 ]. Th2 responses are initiated by tissue-resident innate lymphoid cells 2 (ILC2) but also require macrophages, DC and Th cells.…”

Section: Tlr Expression and Function At Mucosal Surfacesmentioning

confidence: 99%

Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma

Kurago¹,

Loveless²

2021

Front. Oral. Health

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This review discusses the microenvironment of evolving and established conventional oral squamous cell carcinoma, by far the most common oral cancer. The focus of this paper is mainly on the more recent data that describe the role of microorganisms, host-microbial interactions, and in particular, the contributions of cell-surface toll-like receptors on immune system cells and on normal and malignant epithelial cells to their functions that support carcinogenesis. Because carcinomas arising at various host surfaces share much in common, additional information available from studies of other carcinomas is included in the discussion. Accumulating evidence reveals the complex toll-like receptor-mediated tumor-supporting input into many aspects of carcinogenesis via malignant cells, stromal immune cells and non-immune cells, complicating the search for effective treatments.

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Section: Tlr Expression and Function At Mucosal Surfacesmentioning

confidence: 99%

Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma

Kurago¹,

Loveless²

2021

Front. Oral. Health

View full text Add to dashboard Cite

show abstract

IFN-γ Promotes, but Dexamethasone Dissociates, Toll-Like Receptor 2/1-Induced Host Responses in Human Macrophages

Abstract: is required for epidermal trafficking of gammadelta-T cells in an IL-23induced model of psoriasiform dermatitis.

Cited by 1 publication

References 15 publications

Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma

Microbial Colonization and Inflammation as Potential Contributors to the Lack of Therapeutic Success in Oral Squamous Cell Carcinoma

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