IFN-γ and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension

Murata, Yukie; Ohteki, Toshiaki; Koyasu, Shigeo; Hamuro, Junji

doi:10.1002/1521-4141(2002010)32:10<2866::aid-immu2866>3.0.co;2-v

Cited by 92 publications

(91 citation statements)

References 45 publications

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“…A hallmark of M1 polarization is the synthesis of the proinflammatory cytokines IL-6, IL-12, and IL-15 (5) and receptors for IL-2R ␣-chain, IL-15R ␣-chain, and IL-7R as previously described in mice (52,53). In the other pole, M2 are characterized by the overexpression of several scavenger receptors able to bind a diverse array of endogenous and foreign molecules (54).…”

Section: Discussionmentioning

confidence: 94%

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Martínez

Gordon

Locati

et al. 2006

The Journal of Immunology

2,023

155

1,929

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Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage differentiation and polarization toward M1 or M2 phenotypes led to the following main results: 1) M-CSF-driven monocyte-to-macrophage differentiation is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic conditions a default shift toward M2 occurs. 3) Modulation of genes involved in metabolic activities is a prominent feature of macrophage differentiation and polarization. 4) Lipid metabolism is a main category of modulated transcripts, with expected up-regulation of cyclo-oxygenase 2 in M1 cells and unexpected cyclo-oxygenase 1 up-regulation in M2 cells. 5) Each step is characterized by a different repertoire of G protein-coupled receptors, with five nucleotide receptors as novel M2-associated genes. 6) The chemokinome of polarized macrophages is profoundly diverse and new differentially expressed chemokines are reported. Thus, transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology.

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Section: Discussionmentioning

confidence: 94%

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Martínez

Gordon

Locati

et al. 2006

The Journal of Immunology

2,023

155

1,929

View full text Add to dashboard Cite

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“…Besides, it is known that interleukin IL-12 (p70) promotes the differentiation of the Th1 cells and the production of IL-2 and IFN-γ thereby supporting cellular immunity, while IL-12 (p40) acts as an antagonist of IL-12 p70 (Suzuki et al 2003;Alam et al 2010). Previous studies have reported that oxidative stress, in particular GSH status, suppresses the IL-12 (p40/p70) production resulting in a Th2 polarized immune response (Murata et al 2002a(Murata et al , 2002bKamide et al 2011). This condition might explain why SIPS and RS exhibit a more defined pro-inflammatory profile than PIIPS.…”

Section: Discussionmentioning

confidence: 99%

Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

Maciel-Barón

Morales-Rosales

Aquino-Cruz

et al. 2016

AGE

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Cellular senescence is a multifactorial phenomenon of growth arrest and distorted function, which has been recognized as an important feature during tumor suppression mechanisms and a contributor to aging. Senescent cells have an altered secretion pattern called Senescence-Associated Secretory Phenotype (SASP) that comprises a complex mix of factors including cytokines, growth factors, chemokines, and matrix metalloproteinases. SASP has been related with local inflammation that leads to cellular transformation and neurodegenerative diseases. Various pathways for senescence induction have been proposed; the most studied is replicative senescence due to telomere attrition called replicative senescence (RS). However, senescence can be prematurely achieved when cells are exposed to diverse stimuli such as oxidative stress (stressinduced premature senescence, SIPS) or proteasome inhibition (proteasome inhibition-induced premature senescence, PIIPS). SASP has been characterized in RS and SIPS but not in PIIPS. Hence, our aim was to determine SASP components in primary lung fibroblasts obtained from CD-1 mice induced to senescence by PIIPS and compare them to RS and SIPS. Our results showed important variations in the 62 cytokines analyzed, while SIPS and RS showed an increase in the secretion of most cytokines, and in PIIPS only 13 were incremented. Variations in glutathione-redox balance were also observed in SIPS and RS, and not in PIIPS. All senescence types SASP displayed a pro-inflammatory profile and increased proliferation in L929 mice fibroblasts exposed to SASP. However, the behavior observed was not exactly the same, suggesting that the senescence induction pathway might encompass dissimilar responses in adjacent cells and promote different outcomes.

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“…is associated with upregulation of a whole gamut of proinflammatory cytokines such as IL-1 (Scannell, 1996), IL-6 (Albina et al, 1995), IFN- (Murata et al, 2002) and TNF- (White et al, 2004). It is thought that both low oxygen levels and their downstream effects, such as lactate production, may give rise to this macrophage phenotype.…”

Section: Metabolic Inflammationmentioning

confidence: 99%

Metabolomics in the Analysis of Inflammatory Diseases

et al. 2012

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IFN-γ and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension

Cited by 92 publications

References 45 publications

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

Metabolomics in the Analysis of Inflammatory Diseases

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