IFN-α therapy of renal cell carcinoma: Questions regarding cellular immunotherapy

Characiejus, Dainius; Pašukonienė, VP Vita; Kazlauskaitė, Nijolė; Mauricas, Mykolas

doi:10.1016/s0959-8049(97)89367-7

Cited by 1 publication

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“…The identification of predictive immune biomarkers could dramatically increase the response rates of immunotherapy and reduce cost and unnecessary toxicity in subgroups of patients. Immunotherapy, by definition, involves immunological events and it is therefore highly likely that immune parameters or patient‐specific immune signatures will be the best candidates for distinguishing responders from nonresponders . Immune biomarkers do not necessarily have to have a direct association with immune protection and may even indicate the opposite (e.g., markers of immune suppression).…”

Section: Clinical Utility Of Tumor Antigens and Antitumor Antibodiesmentioning

confidence: 99%

Secreted Tumor Antigens – Immune Biomarkers for Diagnosis and Therapy

Meeusen

Lim

2017

Proteomics

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With the advent of immunotherapies for cancer, there is growing interest in the identification of tumor antigens. Tumor antigens are self-molecules altered through e.g. genetic mutations (neoantigens), protein truncation, protein misfolding, or abnormal posttranslational modifications. To induce an immune response, tumor antigens need to be secreted into the tumor environment and presented to the immune system in the draining lymph nodes, resulting in the generation of tumor-specific effector cells and antibodies. Cytotoxic T cells are thought to be responsible for killing of tumor cells, and several recent studies have used MS, combined with exome/transcriptome sequencing and bioinformatics, to identify their cognate peptide ligands on tumor MHC class I molecules. Circulating (serum) antibodies have been more widely used to identify tumor antigens in a range of human cancers, using 2D Western blots, immunoaffinity, and microarray technologies. More specific antibody probes have been generated by harvesting antibodies directly from antibody-secreting cells through in vitro cultures of lymph node cells (antibody-secreting cells probes) or B-cell immortalization. Further identification and characterization of tumor antigens is likely to have important implications for cancer diagnostic and biomarker discovery, immune profiling, and the development of cancer vaccines and targeted immunotherapies.

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Section: Clinical Utility Of Tumor Antigens and Antitumor Antibodiesmentioning

confidence: 99%