IFN-α induces IL-10 production and tilt the balance between Th1 and Th17 in Behçet disease

Interleukin-37 expression is decreased in Behçet's disease and is associated with inflammation

“…The pathogenesis of BD disease has been extensively studied during recent years and various cytokines were shown to be involved in its pathogenesis [17][18]. To investigate whether IL-37 has a role in the pathogenesis of BD, we first compared the expression of IL-37 in active and inactive BD patients.…”

“…Published data have shown that blocking inflammatory cytokines significantly improved the evolution of BD patients [17,34,35]. Touzot et al showed that IFN-␣ promotes a regulatory Th1 response through IL-10 secretion [17].…”

“…Because of the important role of IL-17 in the pathogenesis of BD [17], experiment was performed to examine the role of IL-37 on its production by CD4 + T cells. ELISA determined the concentration of cytokines in the supernatants of CD4 + cells obtained from healthy controls and active BD patients, stimulated with anti-CD3/CD28 or anti-CD3/CD28 plus rIL-37.…”

Dermatophagoides pteronyssinus group 2 allergen bound to 8-OH modified adenine reduces the Th2-mediated airway inflammation without inducing a Th17 response and autoimmunity

“…We showed that the nDer p2-Conj was able to induce IL-27 production in vitro, known to inhibit Th17 cells in both an IL-10-dependent and an independent manner (Pot et al, 2011;Touzot et al, 2015). At the moment, we cannot rule out an IL-27-mediated, IL-10 independent mechanism in our models.…”

The anti-Inflammatory activity of Interleukin-37 in Behçet’s disease

“…Peripheral blood mononuclear cells (PBMCs) and inflammatory sites (skin lesions, cerebrospinal fluid, bronchoalveolar lavage) from patients with BD expressed dysregulated Th1/Th2, Th17/Treg ratios [10][11] . Multiple studies demonstrated that inflammatory mediators are highly expressed in patients with BD compared to healthy controls [12] , mainly represented by Th1 and Th17 cells cytokines.…”