IFN-<i>γ</i>Priming Effects on the Maintenance of Effector Memory CD4<sup>+</sup>T Cells and on Phagocyte Function: Evidences from Infectious Diseases

Silva, Henrique Borges da; Fonseca, Raíssa; Álvarez, José María; Lima, Maria Regina D’Império

doi:10.1155/2015/202816

Cited by 26 publications

(22 citation statements)

References 99 publications

(131 reference statements)

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“…IL-1β is specifically associated with acute and chronic inflammation, and has emerged as a therapeutic target for an expanding number of systemic and local inflammatory conditions called autoinflammatory diseases [28]. IFN-β, is also known to sensitize cells to TLR agonists, thereby boosting the releases of inflammatory mediators [29]. MCP-1 by regulating the migration and infiltration of monocytes/macrophages also plays an important role in inflammatory diseases [30].…”

Section: Discussionmentioning

confidence: 99%

In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophora flavescens

Cho¹,

Nchang

Kim

et al. 2020

Molecules

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Kushenol C (KC) is a prenylated flavonoid isolated from the roots of Sophora flavescens aiton. Little is known about its anti-inflammatory and anti-oxidative stress activities. Here, we investigated the anti-inflammatory and anti-oxidative stress effects of KC in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, and tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells. The results demonstrated that KC dose-dependently suppressed the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. The study demonstrated that the inhibition of STAT1, STAT6, and NF-κB activations by KC might have been responsible for the inhibition of NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in the LPS-stimulated RAW264.7 macrophages. KC also upregulated the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. The upregulation of Nrf2 transcription activities by KC in the LPS-stimulated RAW264.7 macrophages was demonstrated to be responsible for the upregulation of HO-1 expression and its activity in LPS-stimulated RAW264.7 macrophages. In HaCaT cells, KC prevented DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevented reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells. The upregulated activation of Nrf2 and Akt in the PI3K-Akt signaling pathway by KC was demonstrated to be responsible for the anti-oxidative stress activity of KC in HaCaT cells. Collectively, the study suggests that KC can be further investigated as a potential anti-inflammatory candidate for the treatment of inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophora flavescens

Cho¹,

Nchang

Kim

et al. 2020

Molecules

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“…It is generally accepted that there are both IFN-γ-dependent and -independent mechanisms that aid in the clearance of primary genital C. muridarum infection ( 4 , 17 ). IFN-γ is secreted in large quantities by CD4 + T cells during chlamydial infection and is known to play a role in immunoglobulin class switching, B cell maturation, and activation of several immune cell populations and processes during bacterial infections ( 19 , 31 – 37 ). In our current study, however, we identify a new role for IFN-γ in the protective antibody response against C. muridarum reinfection.…”

Section: Discussionmentioning

confidence: 99%

Gamma Interferon Is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia Infection

Naglak

Morrison

2016

Infect Immun

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Defining the mechanisms of immunity conferred by the combination of antibody and CD4+ T cells is fundamental to designing an efficacious chlamydial vaccine. Using the Chlamydia muridarum genital infection model of mice, which replicates many features of human C. trachomatis infection and avoids the characteristic low virulence of C. trachomatis in the mouse, we previously demonstrated a significant role for antibody in immunity to chlamydial infection. We found that antibody alone was not protective. Instead, protection appeared to be conferred through an undefined antibody-cell interaction. Using gene knockout mice and in vivo cellular depletion methods, our data suggest that antibody-mediated protection is dependent on the activation of an effector cell population in genital tract tissues by CD4+ T cells. Furthermore, the CD4+ T cell-secreted cytokine gamma interferon (IFN-γ) was found to be a key component of the protective antibody response. The protective function of IFN-γ was not related to the immunoglobulin class or to the magnitude of the Chlamydia-specific antibody response or to recruitment of an effector cell population to genital tract tissue. Rather, IFN-γ appears to be necessary for activation of the effector cell population that functions in antibody-mediated chlamydial immunity. Our results confirm the central role of antibody in immunity to chlamydia reinfection and demonstrate a key function for IFN-γ in antibody-mediated protection.

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“…In this type of relapsing-remitting ADs, immune cells are constitutively and constantly exposed to waves of significantly "high" (relapse or flare state) or "low" (remission state) levels of type I and type II IFNs during distinct periods of time (56,57). Pre-exposure to low sub-activating concentrations of IFNs sensitizes cells to produce enhanced responses to extracellular inflammatory stimuli that include IFNs themselves, as well as other cytokines such as tumor necrosis factor ␣ (TNF␣) or tolllike receptor activators (58). This process, known as priming, is characterized by the intracellular accumulation of STATs.…”

Section: Chronic Exposure To Ifn␥ Leads To Adsmentioning

confidence: 99%

Current prospects of type II interferon γ signaling and autoimmunity

Green

Young

Valencia

2017

Journal of Biological Chemistry

139

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Edited by Charles E. SamuelInterferon ␥ (IFN␥) is a pleiotropic protein secreted by immune cells. IFN␥ signals through the IFN␥ receptor, a protein complex that mediates downstream signaling events. Studies into IFN␥ signaling have provided insight into the general concepts of receptor signaling, receptor internalization, regulation of distinct signaling pathways, and transcriptional regulation. Although IFN␥ is the central mediator of the adaptive immune response to pathogens, it has been shown to be involved in several non-infectious physiological processes. This review will provide an introduction into IFN␥ signaling biology and the functional roles of IFN␥ in the autoimmune response.According to the National Institutes of Health, autoimmune diseases (ADs) 3 are one of the top 10 leading causes of death in female children and women in all age groups up to 64 years of age (1). Excess secretion of IFNs has been associated with development of human ADs (2). Interferons (IFNs) comprise a family of proteins classified as type I (IFN-␣, -␤, -⑀, -, and -), type II (IFN-␥, herein IFN␥), and type III (IFN-1-4) that have pleiotropic roles in immunity, cancer biology, and autoimmunity (2). Here, we aim to provide a basic understanding of the functions of the type II IFN␥ and the IFN␥-signaling pathway (hereafter referred to as IFN signaling) in a contextual and timing perspective related to the autoimmune environment and the development of ADs.

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IFN-γPriming Effects on the Maintenance of Effector Memory CD4⁺T Cells and on Phagocyte Function: Evidences from Infectious Diseases

Cited by 26 publications

References 99 publications

In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophora flavescens

In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophora flavescens

Gamma Interferon Is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia Infection

Current prospects of type II interferon γ signaling and autoimmunity

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IFN-γPriming Effects on the Maintenance of Effector Memory CD4+T Cells and on Phagocyte Function: Evidences from Infectious Diseases

Cited by 26 publications

References 99 publications

In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophora flavescens

In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophora flavescens

Gamma Interferon Is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia Infection

Current prospects of type II interferon γ signaling and autoimmunity

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Product

Resources

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IFN-γPriming Effects on the Maintenance of Effector Memory CD4⁺T Cells and on Phagocyte Function: Evidences from Infectious Diseases