IFN‐<i>γ</i>‐Mediated Inhibition of COX‐2 Expression in the Placenta from Term and Preterm Labor Pregnancies

Hanna, Nazeeh; Bonifacio, Lea; Reddy, Pradeep; Hanna, Iman; Weinberger, Barry; Murphy, Shaun; Laskin, Debra L.; Sharma, Surendra

doi:10.1111/j.1600-0897.2004.00162.x

Cited by 32 publications

(27 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Here, we present data which demonstrate that IFNg inhibits the expression of COX-2, an important promoter of intestinal tumorigenesis and a target of pharmacological chemopreventive agents. Although IFNg activates COX-2 expression in macrophages (Blanco et al, 2000) and epidermal keratinocytes (Matsuura et al, 1999), it has been shown to downregulate COX-2 in glioma cells (Janabi et al, 2004), in the placenta (Hanna et al, 2004) and to inhibit TNF-induced COX-2 expression in colonic epithelial cells (Wright et al, 2004). In this report, we established that in IECs both IFNg and IFNb inhibit basal COX-2 expression at the transcriptional level in a JAKdependent, but STAT1-independent pathway.…”

Section: Discussionmentioning

confidence: 58%

STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation

et al. 2006

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 58%

STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation

et al. 2006

View full text Add to dashboard Cite

“…Other research has reported miR-143 to be a pivotal regulator of cellular activities, targeting multiple mRNAs involved in cell proliferation, survival and apoptosis. For example, overexpression of miR-143 repressed cell proliferation in melanoma and gastric cancer by targeting syndecan-1 (41) and cyclooxygenase-2 (42), which are also expressed in the placenta (43,44). This may partially explain the downregulation of miR-143 in macrosomic placenta demonstrated in the current study.…”

mentioning

confidence: 51%

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Zhang

Cai

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. Macrosomia, a birth weight ≥4,000 g, is associated with maternal and infant health problems. The dysregulation of microRNAs (miRNAs) in the placenta is associated with adverse birth outcomes, yet whether aberrantly expressed placental miRNAs are associated with macrosomia remains unknown. The aim of the current study was to characterize the expression of three placental miRNAs (miR-6, -21 and -143) and evaluate their association with macrosomia. The miRNA expression in placental tissues from 67 macrosomic pregnancies and 64 normal pregnancies were analyzed using reverse transcription-quantitative polymerase chain reaction. The expression of miR-21 was observed to be elevated in macrosomic placenta compared with control samples, while miR-143 expression was significantly lower than in control placenta (P<0.05). No significant differences were identified in the miR-16 expression levels between the groups (P= 0.955). Following division of miRNA expression levels by quartile, logistic regression models demonstrated that the odds of macrosomia increased with miR-21 expression quartile: Q2, odds ratio (OR)=6.67 [95% confidence interval (CI), 1.39-32.05]; Q3, OR=4.10 (95% CI, 0.88-19.11); Q4, OR=16.19 (95% CI, 2.46-106.68). Conversely, higher levels of miR-143 expression were protective against macrosomia: Q2, OR= 0.22 (95% CI, 0.049-0.98); Q3, OR= 0.11 (95% CI, 0.024-0.55), and Q4, OR= 0.16 (95% CI, 0.032-0.79). Thus, statistical analysis demonstrated that high levels of miR-21 expression and low levels of miR-143 expression predict the risk for macrosomia, indicating an interaction between the two miRNAs. Bioinformatic analysis suggested that they are likely to function in the mitogen-activated protein kinases signaling pathway to influence the risk of macrosomia. The results of the present study provide evidence that placental miR-21 and -143 are important in the formation of macrosomia.

show abstract

“…Thus, lower plasma IFN-γ concentrations may indicate a contributory role for IFN-γ in parturition [42] . Another study proposed that the withdrawal of IFN-γ may be involved in the onset of preterm or term labor by the upregulation of cyclooxygenase expression and prostaglandin E 2 production [43] . Moreover, IL-35 is required for the T-cell-independent induction of IFN-γ, and it is important for the differentiation of both Th1 and Th2 cells [44] .…”

Section: Discussionmentioning

confidence: 99%

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Reyes-Lagos

Peña-Castillo

Pérez‐Sánchez³

et al. 2017

Neuroimmunomodulation

View full text Add to dashboard Cite

Labor is regarded as increased myometrial activity with a regular contractility pattern. At this final stage of pregnancy, myometrial quiescence is lost, accompanied by altered immune homeostasis. It is well known that the interleukin (IL)-10 family of cytokines modulates immunological responses mainly in epithelial cells, including the endometrium. To investigate their inflammatory profile during labor, we performed a longitudinal study in a group of healthy pregnant women (n = 20) with uncomplicated pregnancies in the third trimester of pregnancy and during active labor. Blood was sampled from pregnant women in the third trimester (gestational age 32-38 weeks, mean 36 ± 2 weeks) and during active labor (39-41 weeks of gestation, mean 40 ± 1 weeks). Serum levels of several cytokines were measured using multiplex immunoassays for both stages, indicating that the concentrations of IL-10, IL-20, IL-22, IL-28A, and interferon (IFN)-γ were significantly decreased during active labor in comparison with third-trimester levels (p < 0.05). Our analysis did not find significant correlations between IL-10, IL-20, IL-22, IL-28A, and IFN-γ levels and gestational age. However, our data suggest that the systemic downregulation of several members of the IL-10 family of cytokines plays an important role in the activation of myometrial smooth cells associated with uterine contractions during active labor. Downregulation of this IL-10 family of cytokines seems to coincide with the well-reported functional progesterone withdrawal during labor. Likewise, lower plasma IFN-γ concentrations may indicate a role for IFN-γ in active labor.

show abstract

IFN‐γ‐Mediated Inhibition of COX‐2 Expression in the Placenta from Term and Preterm Labor Pregnancies

Abstract: Our data suggest that the human placenta is an important site for IFN-gamma-mediated repression of COX-2 expression and PGE2 production, implying that functional withdrawal of IFN-gamma may be involved in the onset of term or preterm labor.

Cited by 32 publications

References 39 publications

STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation

STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Contact Info

Product

Resources

About

IFN‐γ‐Mediated Inhibition of COX‐2 Expression in the Placenta from Term and Preterm Labor Pregnancies

Abstract: Our data suggest that the human placenta is an important site for IFN-gamma-mediated repression of COX-2 expression and PGE2 production, implying that functional withdrawal of IFN-gamma may be involved in the onset of term or preterm labor.

Cited by 32 publications

References 39 publications

STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation

STAT1-independent inhibition of cyclooxygenase-2 expression by IFNγ; a common pathway of IFNγ-mediated gene repression but not gene activation

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-&#x03B3; Decrease from the Third Trimester of Pregnancy to Active Labor

Contact Info

Product

Resources

About

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor