IFATS Collection: Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells in an Allergic Rhinitis Mouse Model

Abstract

ABSTRACT

Allogeneic and Xenogeneic Transplantation of Adipose-Derived Stem Cells in Immunocompetent Recipients Without Immunosuppressants

“…However, the antibodies were determined to be noncytotoxic and thus not expected to impede the prospective implementation of allogeneic ADSC for spinal fusion. In an allergic rhinitis mouse model IV injected ADSCs were found to migrate to the nasal mucosa, reduce allergic symptoms, and inhibit eosinophilic inflammation in the nasal mucosa [60]. ADSCs also significantly decreased the allergen-specific IgE level and IgG1/IgG2a ratio, suggesting the inhibition of eosinophilic inflammation was due to a shift from a Th2 immune response to a T-helper response.…”

In vitromigration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors

“…(Mizuno, 2010). Local or systemic administration of AdMSCs was reported to induce repair of myocardial infarction (Cai et al, 2009), liver injury (Banas et al, 2008), hypoxia-ischemia-induced brain damage (Wei et al, 2009), allergic rhinitis (Cho et al, 2009) and muscular dystrophy (Bacou et al, 2004). One of the more interesting characteristics of MSCs is their ability to migrate to areas of tissue injury.…”

“…A recent study dem onstrated the hom ing properties of intravenously administered AdMSCs to cell-damaged areas in an allergic rhinitis animal model (Cho et al, 2009). However, the soluble factors and receptors that are responsible for inducing chemotaxis of AdMSCs have not yet been identified.…”

Adipose-derived stromal/stem cells

“…Independent teams have reported positive outcomes in murine models of allergic rhinitis, arthritis, graft vs. host disease, and systemic lupus erythematosis. [45][46][47][48] The 49 This correlated with increased levels of cytokines associated with Th2 helper cells, such as interleukin 4 and 10. 49 Both murine and human SVF cells and ASCs delivered intraperitoneally at the time of antigen exposure offered comparable protection in the murine EAE model (B. Bunnell, manuscript in preparation).…”