This paper contributes to anthropological debates surrounding borderlands and biosecurity by tracing the multiple pursuits of protection that emerge between the state and minorities during infectious disease outbreaks. Drawing on an ethnographic study into child health in Jerusalem following epidemics of measles and COVID-19, the paper demonstrates how responses to public health interventions are less about 'compliance' or 'indiscipline' than a competing pursuit of immunity to preserve religiously Orthodox lifeworlds. The voices of religiously Orthodox Jews are situated alongside printed broadsides (pashkevilim) that circulated anonymous truth-claims in Jerusalem neighborhoods, which cast state intervention against historical narratives of deception and ethical failures. Borderland tensions, like a virus, mutate and influence responses to authority and biosecurity, and reconfigure vernacular entanglements of religion, state, and health. The paper encourages anthropologists and public health specialists to consider non-vaccination beyond a COVID-19 silo, and as part of situated relations between the state and minority populations.