İdrar N-Asetil-Beta-D-Glukosaminidaz Aktivitesi: İki Farklı Tayin Yönteminin Karşılaştırılması

Abstract

DAHİLİ BİLİMLER / MEDICAL SCIENCESAraştırma Material-Methods:We measured urinary NAG levels using PNP-NAG and MCP-NAG substrates in 40 healty persons, and in 40 renal failure patients. We also tested the effect of gel filtration on PNP-NAG method. Results:The urinary NAG levels measured by two different substrates were 27.5 u/L and 16.5 u/L in chronic renal failure group, 5.66 U/L and 3.62 U/L in control group. The differences between two groups were significant (p<0.001). Conclusion:The measurement of urinary NAG levels using PNP-NAG substrate is an easy, efficacious and cost effective method and the measurment range is wider comparing with MCP-NAG. This method may take part in the determination and management of renal tubular injury.