Abstract:The power of structural information for informing biological mechanism is clear for stable folded macromolecules, but similar structure-function insight is more difficult to obtain for highly dynamic systems such as intrinsically disordered proteins (IDPs) which must be described as structural ensembles. Here we present IDPConformerGenerator, a flexible, modular open source software platform for generating large and diverse ensembles of disordered protein states that builds conformers that obey geometric, ster… Show more
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