In this paper we consider irreducible holomorphic symplectic sixfolds of the sporadic deformation type discovered by O'Grady, and their symplectic birational transformations of finite order. We study the induced isometries on the Beauville-Bogomolov-Fujiki lattice, classifying all possible invariant and coinvariant sublattices, and providing explicit examples. As a consequence, we show that the isometry induced by a symplectic automorphism of finite order is necessarily trivial. This paper is a first step towards the classification of all finite groups of symplectic birational transformations.