Idiotype Network

Lemke, Hilmar

doi:10.1007/978-3-642-27786-3_733-2

Cited by 1 publication

(1 citation statement)

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“…These idiotypes (Ab1) are able to identify antigens and are recognised by Ab2 to maintain homeostasis of the immune system [ 44 ]. During homeostasis, the presence of epitopes or antigenic determinants stimulate the production of antigen-specific antibodies (Ab1), which subsequently induce the production of anti-ID antibodies (Ab2) to maintain equilibrium [ 45 ]. Ab2 are classified into Ab2α, Ab2β or Ab2γ depending on their antigen-binding sites ( Figure 1 ).…”

Section: Anti-id Antibodies In the Idiotypic Network Theorymentioning

confidence: 99%

Immunomodulatory Potential of anti-idiotypic Antibodies for the Treatment of Autoimmune Diseases

Pan¹,

Chia²,

Yee³

et al. 2020

Future Sci. OA

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The immune system is a complex network of specialized cells and organs that recognises and reacts against foreign pathogens while remaining unresponsive to host tissues. This ability to self-tolerate is known as immunological tolerance. Autoimmune disease occurs when the immune system fails to differentiate between self and non-self antigens and releases autoantibodies to attack our own cells. Anti-idiotypic (anti-ID) antibodies are important in maintaining a balanced idiotypic regulatory network by neutralising and inhibiting the secretion of autoantibodies. Recently, anti-ID antibodies have been advanced as an alternative form of immunotherapy as they can specifically target autoantibodies, cause less toxicity and side effects, and could provide long-lasting immunity. This review article discusses the immunomodulatory potential of anti-ID antibodies for the treatment of autoimmune diseases.

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Section: Anti-id Antibodies In the Idiotypic Network Theorymentioning

confidence: 99%