Idiosyncratic drug-induced agranulocytosis: Update of an old disorder

A Confirmed Case of Agranulocytosis after Use of Cocaine Contaminated with Levamisole

“…There are many known toxic and infectious causes of agranulocytosis [18,19]. In the suspected cases, we reviewed at our institution, we found several in which, after an exhaustive negative workup, agranulocytosis was attributed to unspecified viral illness, atypical presentations of autoimmune diseases such as systemic lupus, or to a common medication, such as trimethoprim/sulfamethoxazole or risperidal [18,19].…”

“…In the suspected cases, we reviewed at our institution, we found several in which, after an exhaustive negative workup, agranulocytosis was attributed to unspecified viral illness, atypical presentations of autoimmune diseases such as systemic lupus, or to a common medication, such as trimethoprim/sulfamethoxazole or risperidal [18,19]. In some cases, agranulocytosis persisted or recurred after exposure to the ostensible offending agent was discontinued and cocaine use continued.…”

Prolonged infection byFonsecaea pedrosoiafter antigenic co-stimulation at different sites in experimental murine chromoblastomycosis

“…34,35 Therefore, compromising or suppressing their function increases host vulnerability to fungal infection. 36 Infectious tolerance caused by humoral or cellular factors may suppress neutrophilic activity by means similar to infections by Aspergillus fumigatus.…”

Update on the Incidence of Metamizole Sodium-Induced Blood Dyscrasias in Poland

“…12 An association between HLA-B27 and HLA-B38 and increased risk of agranulocytosis with clozapine has also been reported. 13 Patients who receive clozapine need to have their full blood counts monitored regularly and, if the total white cell and/or neutrophil counts indicate agranulocytosis, clozapine must be terminated. 14 Testing the involvement of a genetic link to this, however, would require DNA sampling and assessment of each patient.…”