Idiopathic thrombocytopenic purpura with venous thrombosis: A case report

Management of Recurrent Venous Thromboembolism in Severe Immune Thrombocytopenia: A Case Report and a Review of the Literature

“…20 While other thrombophilic conditions such as APS are commonly associated with both ITP and thrombotic events, 17 only very few cases of ITP patients are complicated by FVL. 1,8 Thrombophilia investigation of our case also showed an increased level of PAI-1, which can be presumed to be related to his obesity. Furthermore, the patient had slightly low antithrombin activity (77%) and normal antigen level, which is unlikely to have clinical significance.…”

“…The data of all 15 patients including our case are presented in ►Table 2. 1,[6][7][8][9][10][11][12][13] The underlying pathogenesis behind this prothrombotic tendency in patients with ITP is unclear. 14 Several different possible causes have been suggested including hyperactive immature platelets, 15 platelet microparticles, 14 and dysfunction in complement activation.…”

Thrombosis and risk factors

“…And also the two patients with high homocysteine levels did not have 677 T polymorphism [1]. İlhan et al's patient was heterozygous for 677 T with normal homocysteine level [2]. These reports indicated a very interesting point.…”

“…I read the three papers related to thrombosis, appeared in the recent issue of the journal with great interest [1][2][3]. Yokuş et al described their patients with cerebral vein thrombosis and evaluated the risk factors for thrombosis.…”