Idiopathic thrombocytopenic purpura: Pathophysiology and management

Abstract

Our understanding of the pathophysiology of ITP owes to pioneering work of W J Harrington in 1951, delineating the immunologic nature of platelet destruction. In ITP, antibody-coated platelets are destroyed by macrophages of RES. However, other mechanisms are also implicated: C-mediated platelet lysis and newly described C-independent peroxide injury. Both induce platelet fragmentation and lysis, generating procoagulant platelet microparticles (PMP). A third mechanism of platelet consumption in the microvasculature is proposed, based on overlapping syndromes of ITP and TTP in some patients. In assessing hemostasis in ITP, platelet counts alone is not sufficient. Evaluation of platelet clumping, giant platelets, and platelet activation, marked by increased PMP is useful. Patients with platelet activation or giant platelets bleed less and detection of clumping prevents unwarranted therapy. Thrombotic complications may develop in ITP. A syndrome, characterized by recurrent TIA-like symptoms, progressive memory loss due to ischemic small vessel disease is described. The management of ITP should include the search for and elimination of underlying causes and careful evaluation of hemostasis. Therapy is divided into definitive vs symptomatic measures. The former including splenectomy, danazol, chemotherapy offers lasting remission after therapy was stopped, while the later including glucocorticoids, gammaglobuin, antiD antibodies and others increases platelet counts but seldom sustains remission upon withdrawal. Danazol therapy is up-dated since it is an effective and safe definite measure in ITP.

Clinical consideration of thrombocytopenia in children

“…Mostly due to IgG auto body, which bind the platelet by itself. 13 Misdiagnosis of thrombocytopenia sometimes happen. In a research by Bader-Meunier et al, was found that children the suspected diagnosis on referral was autoimmune thrombocytophenic purpura and the final diagnosis was inherited thrombocytopenia.…”

Severe Ischemic Stroke in a Patients with Idiopathic Thrombocytopenic Purpura: A Case Report

“…Consequently, they lead to thrombocytopenia and generally to bleeding diathesis (1,2). Nevertheless, ITP, even rare, may lead to thrombotic complications, including ischemic stroke (2,3). Herein, we reported a female case with ITP who developed cerebral infarction due to the thrombus in the middle cerebral artery (MCA).…”

“…In ITP, antibodies bind to platelet-specific antigens, and antibody-bound platelets are removed from circulation by splenic macrophages. Consequently, they lead to thrombocytopenia and generally to bleeding diathesis (1,2). Nevertheless, ITP, even rare, may lead to thrombotic complications, including ischemic stroke (2,3).…”

Danazol one Month Treatment of Thrombocytopenia in Chronic Hepatitis C

“…There are some reports regarding hepatotoxic effects of Danazol after more than 2 years of use, but no reports of adverse effects during short time periods [11,12].…”