Idiopathic Subglottic Stenosis in Non‐Caucasian Women

Abstract

ObjectiveTo characterize presentation, disease course, and treatment of idiopathic subglottic stenosis (iSGS) in non‐Caucasian women and compare this cohort to the predominantly female, Caucasian patient cohorts identified in the literature.Study DesignRetrospective review. Results are compared to systematic review of demographics.SettingMultiple California institutions from 2008 to 2021.MethodsPatients with intubation within 2 years of disease or who met exclusion criteria listed in prior publications were excluded. A systematic review of iSGS patient demographics was also completed for comparison.ResultsOf 421 patients with iSGS, 58 self‐identified as non‐Caucasian women, with 50 ultimately included. Mean age of onset was 45.1 years old (95% confidence interval [CI], 41.5‐48.8), and mean age at diagnosis was 47.2 years (95% CI, 43.6‐50.7). Mean Charlson comorbidity index was 1.06 (n = 49, 95% CI, 0.69‐1.44). At diagnosis, Cotton‐Meyer severity scores (documented in n = 45) were Cotton‐Myer (CM) I (28.9%), CM II (40%), and CM III (31.1%). Mean age at first endoscopic surgery was 47.7 (95% CI, 44.2‐51.3) years. 64% experienced disease recurrence with a median of 11 months between their first and second surgery. Our systematic review identified 60 studies that reported demographic features in patients with iSGS. 95% of pooled patients were Caucasian, while other demographic features were similar to the current cohort.ConclusionThe non‐Caucasian population, almost 14% of this Californian cohort, does not differ from the majority Caucasian population detailed in contemporary literature. This cohort supports the presence of some racial and ethnic heterogeneity in this disease population.