Idiopathic scoliosis from the point of view of the neuroradiologist

Roth, M

doi:10.1007/bf00339521

Cited by 37 publications

(2 citation statements)

References 6 publications

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“…Roth hypothesized that spinal cord stretching is responsible for scoliosis and Arnold-Chiari syndrome type 1. 20 Porter considered uncoupled-osseus development to be the cause of idiopathic scoliosis. 21 , 22 Lowe et al have suggested that neurological dysfunction plays a key role in the genesis of idiopathic scoliosis.…”

Section: Discussionmentioning

confidence: 99%

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Neuro-cranio-vertebral syndrome related to coccygeal dislocation: A preliminary study

Royo-Salvador,

Fiallos-Rivera,

Villavicencio

2024

World Neurosurgery: X

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Section: Discussionmentioning

confidence: 99%

“… 23 Finally, Roth and Porter hypothesized that local neural dysfunction within the spinal cord may cause of idiopathic scoliosis. 20 , 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

Neuro-cranio-vertebral syndrome related to coccygeal dislocation: A preliminary study

Royo-Salvador,

Fiallos-Rivera,

Villavicencio

2024

World Neurosurgery: X

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TIMP2 Polymorphisms Association With Curve Initiation and Progression of Thoracic Idiopathic Scoliosis in the Caucasian Females

Andrusiewicz

Harasymczuk

Janusz

et al. 2019

Journal Orthopaedic Research

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Idiopathic scoliosis (IS) etiology remains unclear, but strong genetic background is suggested. Previously reported TIMP2 study indicates an association of genic rs8179090 with IS progression in a Han Chinese population. However, there has been a lack of investigation into intragenic TIMP2 polymorphisms in IS patients. We recruited 100 Caucasian females with IS and 100 controls. Patients were subdivided accordingly to: progression rate, curve severity, joint mobility, and curve pattern. Allele‐specific‐polymerase chain reaction based on fluorescence resonance energy transfer was applied to evaluate nine TIMP2 polymorphisms. Distribution of genotype and allele frequency in only one polymorphism (rs11658743) differed in case–control study. Four of the polymorphisms (rs2277700, rs11077401, rs2376999, and rs4789934) showed non‐equal distributions either in genotype or/and allele distributions in the patients of different progression rates. The rs11077401 was related to curve severity patients distinction and the rs8179090 distinguished patients with different joint mobility level. Two polymorphisms either differed statistically in case of curve patterns subgrouping (rs8068674 and rs8179090) or showed a slight tendency toward significance in the recessive model of allele distributions (rs9916809 and rs8179090). The remaining two polymorphisms (rs2377005, rs11658743) showed no association with either clinical or radiographic IS characteristics. The influence of the G allele of the rs8179090 on the clinical course of IS has not yet been confirmed. We identified four TIMP2 polymorphisms (rs11077401, rs2376999, rs2277700, and rs4789934) that were associated with a higher risk of the progressive IS form. Further genetic association studies based on suggested clinical criteria would be necessary to validate TIMP2 polymorphisms associated with the curve progression. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2217–2225, 2019

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Cranio-cervical growth collision: another explanation of the Arnold-Chiari malformation and of basilar impression

Roth

1986

Neuroradiology

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Analysis of neuro-cranio-spinal development suggests a cranio-cervical growth conflict as the cause of the Arnold-Chiari malformation and of basilar impression. The ascending course and elongation of the upper cervical nerves associated with the Arnold-Chiari malformation reflects the abnormal, caudo-cranially proceeding growth of the cervical spine. This is the opposite of the normal cranio-caudal direction of growth (which includes the brain) with downward slanting of the cervical nerve roots. The cervical growth reversal is a compensatory event related to the impairment of distal spinal growth at the level of the coexistent myelomeningocele. With the reversal of the cerical growth, the initial descent (uncoiling) of the primordial brain curvatures is compromised owing to the growth-collision with the ascending cervical spine. Their subsequent growth proceeds into the upper cervical spinal canal. The contents of the posterior cranial fossa are actively "sucked up", "devoured" by the latter. In contrast to the adaptively enhanced growth of the early cranio-cervical nervous structures in the Arnold-Chiari malformation, as an answer to the growth-shifts of the encasing skeleton, basilar impression is a postembryonic adaptation of the cervico-cranial skeleton to the inadequate growth of the nervous structures after the latter have lost their growth adaptability. Arnold-Chiari malformation and basilar impression are just two representatives of "osteo-neural growth pathology" encompassing some "dysplastic" disorders of the axial as well as of the limb skeleton such as platyspondyly, scoliosis, Scheuermann's kyphosis, achondroplasia-like conditions, congenital dysplasia of the hip etc.(ABSTRACT TRUNCATED AT 250 WORDS)

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Idiopathic scoliosis from the point of view of the neuroradiologist

Cited by 37 publications

References 6 publications

Neuro-cranio-vertebral syndrome related to coccygeal dislocation: A preliminary study

Neuro-cranio-vertebral syndrome related to coccygeal dislocation: A preliminary study

TIMP2 Polymorphisms Association With Curve Initiation and Progression of Thoracic Idiopathic Scoliosis in the Caucasian Females

Cranio-cervical growth collision: another explanation of the Arnold-Chiari malformation and of basilar impression

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