Idiopathic scoliosis: Etiological concepts and hypotheses

Dayer, Romain; Haumont, T.; Belaieff, Wilson; Lascombes, P.

doi:10.1007/s11832-012-0458-3

Cited by 56 publications

(35 citation statements)

References 67 publications

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“…In another study, serum copper and zinc levels were found to be normal in IS patients [13]. In a different study conducted by Dastych et al, copper levels in the back muscles of IS patients were found to be low, but no significant difference was found in hair, leucocyte, and serum compared to the control group [26].…”

Section: Discussionmentioning

confidence: 86%

“…In some studies, serum selenium levels were found to be low in the scoliosis patients [10,13,14]. In a study for example, selenium levels both in the serum and in hair samples were found to be low in IS patients [14].…”

Section: Discussionmentioning

confidence: 97%

“…Lysyl oxidase is the key copper dependent enzyme in the synthesis and maturation of collagen and collagen fibrils. A proper function of this enzyme system depends on the existence of all of the substrates, cofactors and sufficient quantities of multifunctional trace elements [12,13]. Se, Zn and Cu are important trace elements that take part in collagen synthesis and maturation.…”

Section: Discussionmentioning

confidence: 99%

“…In some studies, it was shown that essential trace elements necessary for the body (selenium, zinc, copper) have roles in synthesis of collagen and elastin and maturation of the body and therefore in the progression of IS [10,11,13]. Selenium, zinc, and copper show their functions through metalloenzymes.…”

Section: Introductionmentioning

confidence: 99%

“…Various studies have shown that deficiency of some trace elements, such as copper and selenium, may cause disruptions in collagen synthesis and maturation [14][15][16]. Some studies suggested that selenium deficiency is a risk factor for IS [10,11,13]; recent studies have also suggested that excess selenium is also a risk factor for IS [17,18]. Consequently whether deficiency or excess of selenium is a bigger risk factor is not yet known.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Yalaki¹,

Özdemir²,

Zengin³

et al. 2017

Dicle Tıp Dergisi

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Objective: The purpose of this study was to investigate the serum levels of selenium, zinc and copper on the etiology of idiopathic scoliosis in adolescents. Methods: Forty four idiopathic scoliosis patients between 10 and 17 years of age were considered in this study. The vertebra curvature degrees of the patients were between 28° and 82°. The idiopathic scoliosis patients were assigned to two groups based on their vertebra curvature degrees. Curvature degree of 45° and lower was labeled as group 1 and curvature of upper 45° was labeled as group 2. Total blood count, serum levels of selenium, zinc and copper were studied. Results: Thirty three of the idiopathic scoliosis patients (75%) were female. There was no statistically significant difference in serum zinc and copper levels between idiopathic scoliosis patients and the control group (p> 0.05). Serum selenium levels in idiopathic scoliosis patients were lower than that of the control group and the difference was statistically significant (p< 0.05). In terms of vertebra curvature degree and demographic characteristics of the patients, group 2 age average was significantly higher than that of the group 1 (p< 0.05). When serum selenium, zinc, and copper levels were compared based on the vertebra curvature degrees of the IS patients, no statistically significant difference was observed between group 1 and 2 in laboratory measurements (p > 0.05). Conclusion: Among the measured trace elements, selenium was lower in the serum of the IS patients. This is the first study in Turkey that we know of about this subject and we think that further studies are needed.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Yalaki¹,

Özdemir²,

Zengin³

et al. 2017

Dicle Tıp Dergisi

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Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1

Chen

Sun

Peng

et al. 2023

Journal Orthopaedic Research

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Many clinical studies have indicated an association between biomechanical factors and the incidence and pathological progression of adolescent idiopathic scoliosis (AIS). However, at present, the research on AIS is mainly focused on the etiology, and there are few studies reporting the causes of progressive aggravation of AIS. In the present study, we aim to investigate the role of Piezo1 in compressive stressinduced mouse spinal vertebral growth plate chondrocytes apoptosis. First, a scoliosis mouse model was established, and the expression of Piezo1 as well as the degree of apoptosis were investigated. We found that the expression of Piezo1 and the degree of apoptosis were significantly higher on the concave sides than that on the convex sides of the vertebral growth plate in mice with scoliosis. Spinal vertebral growth plate chondrocytes were further isolated and treated with Yoda1 to mimic Piezo1 overload. Excess Piezo1 significantly promoted apoptosis of spinal vertebral growth plate chondrocytes. Moreover, static gas compressive stress was used to simulate the increased concave compressive stress in the process of scoliosis with or without GsMTx4, a Piezo inhibitor. It was observed that with the increase of static compressive stress, the expression of Piezo1 increased, and the chondrocytes of vertebral growth plate treated with Piezo1 inhibitor GsMTx4 weakened the above phenomena. In conclusion, our results indicated that compressive stress is strongly associated with the different degrees of apoptosis on both sides on the convex and concave sides of the vertebral growth plate in scoliosis via inducing different expressions of Piezo1. Reducing the expression of Piezo1 in the concave side of the vertebral growth plate and inhibiting the apoptosis of chondrocytes in the bilateral vertebral growth plate caused by asymmetric stress on both sides of the concave vertebral body may be a promising treatment strategy for AIS.

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Skoliose im Wachstumsalter

et al. 2015

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Scoliosis affects up to 6 % of the population. The resulting spine deformity, the increasing risk of back pain, cosmetic aspects, pulmonary disorders if the Cobb angle is > 80°, and the progress of the deformity to > 50° after the end of growth indicate non-operative or operative therapy. In daily clinical practice, the classifications of scoliosis allow the therapy to be adapted. Classifications consider deformity, topography of the scoliosis, and the age at diagnosis. This publication gives an overview of the relevant and most common classifications in the treatment of adolescent scoliosis. For evaluation, the deformity measurement on the coronary radiographic projection of the total spine (Cobb angle) is relevant to therapy. The classification of topography, form, and the sagittal profile of the deformity of the spine are useful for preoperative planning of the fusion level. Classifications that take into account the age at the time of the diagnosis of scoliosis differentiate among early onset scoliosis (younger than 10 years of age), adolescent scoliosis (up to the end of growth), and adult scoliosis. Early onset scoliosis is subdivided by age and etiology. Therapy is derived from the classification of clinical and radiological findings. Classifications that take into account clinical and radiological parameters are essential components of modern scoliosis therapy.

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Idiopathic scoliosis: Etiological concepts and hypotheses

Cited by 56 publications

References 67 publications

Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1

Skoliose im Wachstumsalter

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