Idiopathic Scoliosis: Characteristics and Epidemiology

Smyrnis, Takis; Valavanis, J; Zachariou, C

doi:10.3928/0147-7447-19870601-11

Cited by 14 publications

(2 citation statements)

References 22 publications

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“…When there is no obvious cause, this disease is referred to as idiopathic scoliosis (IS). IS predominantly affects girls and develops during puberty, mostly entailing a right thoracic curve [2,3]. In Sweden, a study on monozygotic and dizygotic twins concluded that the development of scoliosis is explained by genetics for 38%, and by environmental factors for 62% [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cerebrospinal Fluid Flow by Nuclear Magnetic Resonance in Adolescent Idiopathic Scoliosis

ZAVARD,

VERCLYTTE,

CATALA

et al. 2024

Preprint

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Objectives Zebrafish research highlighted the critical role of cilia-driven cerebrospinal flow (CSF) in spine development, establishing CSF flow irregularities as an underlying biological cause of idiopathic scoliosis (IS). In this study, our objective was to assess and compare the cerebrospinal flow (CSF) of two populations (healthy adolescents and adolescents with IS) in order to detect anomalies similar to those in the animal model. Methods We conducted a prospective monocentric case-control study with 6 months of cohort follow-up. We enrolled 34 and 31 adolescents with and without IS, respectively. CSF flow was assessed using a 3T MRI scanner with axial phase-contrast flow sequences at the level of the mesencephalic aqueduct (MA), the 2nd cervical vertebra (C2), and the 7th thoracic vertebra (T7). Results Our results revealed no statistically significant difference in the CSF circulation characteristics (stroke volume, flow, velocity) at all three levels between the two groups. In the IS group, there was a positive correlation between the maximum CSF velocity at C2 and the Cobb angle (p = 0.014). There was also a positive correlation between the stroke volumes at the MA and C2 (p = 0.033), and between the CSF stroke volumes at C2 and T7 (p = 0.0012). Conclusion Our results revealed no difference in CSF flow characteristics between healthy and IS subjects. Further investigations would be pertinent to clarify the role of cerebrospinal fluid in correct spinal morphogenesis in humans.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Cerebrospinal Fluid Flow by Nuclear Magnetic Resonance in Adolescent Idiopathic Scoliosis

ZAVARD,

VERCLYTTE,

CATALA

et al. 2024

Preprint

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“…Monozygotic twins and spinal radiology in adolescent idiopathic scoliosis [77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] Sleeping period of time and sleeping position [38,122].…”

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confidence: 99%

Are the Spinal Changes in the Course of Scoliogeny Primary but Secondary?

Grivas,

Vasiliadis,

Mazioti

et al. 2024

JCM

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In this opinion article, there is an analysis and discussion regarding the effects of growth on the spinal and rib cage deformities, the role of the rib cage in scoliogeny, the lateral spinal profile in adolescent idiopathic scoliosis (AIS), the genetics and epigenetics of AIS, and the interesting and novel field investigating the sleep impact at nighttime on AIS in relation to the sequence of the scoliogenetic changes in scoliotics. The expressed opinions are mainly based on the published peer-reviewed research of the author and his team of co-authors. Based on the analysis noted above, it can be postulated that the vertebral growth changes in the spine during initial idiopathic scoliosis (IS) development are not primary-intrinsic but secondary changes. The primary cause starting the deformity is not located within the vertebral bodies. Instead, the deformations seen in the vertebral bodies are the secondary effects of asymmetrical loads exerted upon them, due to muscular loads, growth, and gravity.

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