Idiopathic Scoliosis

Trobisch, Per; Suess, Olaf; Schwab, Frank J.

doi:10.3238/arztebl.2010.0875

Cited by 146 publications

(179 citation statements)

References 38 publications

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“…Another study comparing Endoret with controls for bilateral sinus floor augmentation in a series of five patients reported typical findings of 20-30% new bone formation in the treated area versus 8% new bone formation in the control area. Based on immunohistochemical analysis, the authors reported 116 blood vessels per mm (Trobisch et al 2010) in the treated area, compared with only 7 per mm (Trobisch et al 2010) in the control area (Anitua et al 2010b). …”

Section: Toward Clinical Impactmentioning

confidence: 98%

“…During childhood and adolescence, deformities during skeletal growth can arise due to genetic defects, infectious disease, and other growth imbalances (Dixon et al 2011;Trobisch et al 2010). In adulthood, osteoarthritis and back pain are major contributors to immobility, pain, and lost productivity (Lories and Luyten 2011;Walker et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Endogenous musculoskeletal tissue engineering - a focused perspective

Adam

2011

Cell Tissue Res

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Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient's autologous cells prior to re-implantation as part of a TE construct, and (2) the potential risks and availability constraints associated with transplanting exogenous (foreign) cells. These hurdles have led to recent interest in endogenous TE strategies, in which the regenerative potential of a patient's own cells is harnessed to promote tissue regrowth without ex vivo cell culture. This article provides a focused perspective on key issues in the development of endogenous TE strategies, progress to date, and suggested future research directions toward endogenous repair and regeneration of musculoskeletal tissues and organs.

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Section: Toward Clinical Impactmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Endogenous musculoskeletal tissue engineering - a focused perspective

Adam

2011

Cell Tissue Res

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“…The AIS may resolve spontaneously, with growth, or may progress severely and even be associated with risk of mortality (1,15). The progressive deformity may cause several body prominences, asymmetric waistline, uneven shoulders, injured self-image, pain, spinal degenerative changes, limitations in activities of daily living and, in severe cases, disturbed pulmonary function (29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Adolescent Idiopathic Scoliosis: Males Versus Females

Mahabadi¹,

Ghandehari²,

Mahdavi³

et al. 2015

Shafa Ortho J

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Background: Treatment of adolescent idiopathic scoliosis (AIS) is one of the most challenging problems for spine surgeons. Although it has been previously demonstrated that curve pattern in AIS is different between males and females, there are, however, limited studies specially focused on the differences of AIS characteristics between the two genders. Objectives: In current study, we compared the demographics and curve patterns in male and female patients with AIS. Patients and Methods: A total of 68 girls and 17 boys with AIS were included in this cross-sectional study. The magnitude of curvature, thoracic kyphosis, flexibility and pattern of the deformity were measured on x-rays and compared between the two genders. Results: Although girls were significantly younger (15.3 ± 2.5 versus 16.7 ± 2.1 years; P = 0.036), however, the Risser sign was the same. Most of the males were hypokyphotic (70.6%), while most of the girls had normal thoracic kyphosis (69.1%) (P = 0.001). The main scoliotic curve (77.2 ± 18.2 versus 59.6 ± 18.6 degrees) and flexibility (25.5% ± 18.2% versus 41.9% ± 18.6%) were significantly greater and lower in males, respectively (P < 0.05). The typical AIS pattern was present in 64.7% of boys and 95.6% of girls (P < 0.001). Conclusions:The radiographic characteristics of AIS are substantially different between genders. In male patients, AIS is more severe and rigid compared to females. Also, hypokyphosis and atypical pattern of AIS are common findings in males compared to females.

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“…Scoliosis is a medical condition in which a person's spinal axis has a three-dimensional deviation [4]. It is typically classified as either congenital (15%) idiopathic (65%) or secondary (10%) to a primary condition.…”

Section: Scoliosismentioning

confidence: 99%