Idiopathic pulmonary hemosiderosis: A state of the art review

Saha, Biplab K.

doi:10.1016/j.rmed.2020.106234

Cited by 47 publications

(81 citation statements)

References 77 publications

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“…No hemorrhagic focus nor foreign bodies can be found on bronchoscopy. In particular, DD should consider IPH, that includes the classic triad hemoptysis, radiologic lung infiltrate and iron deficiency anemia, having a more severe course and prognosis [ 22 ]. Moreover, IPH occurs in older children, and it is rarely associated with gastrointestinal symptoms [ 23 ] ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence

et al. 2021

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Infants affected by Heiner syndrome (HS) display chronic upper or lower respiratory tract infections, including otitis media or pneumonia. Clinically, gastrointestinal signs and symptoms, anemia, recurrent fever and failure to thrive can be also present. Chest X-rays can show patchy infiltrates miming pneumonia. Clinical manifestations usually disappear after a milk-free diet. The pathogenetic mechanism underlying HS remains unexplained, but the formation of immune complexes and the cell-mediated reaction have been proposed. Patients usually outgrow this hypersensitivity within a few years. The aim of this review is to provide an updated overview on the current evidence on HS in children, with a critical approach on the still undefined points of this interesting disease. Finally, we propose the first structured diagnostic approach for HS.

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Section: Discussionmentioning

confidence: 99%

Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence

et al. 2021

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“…Classically, DAH manifests with hemoptysis, radiologic chest infiltrates, and anemia [5,6]. However, the complete triad is present in only a minority of patients.…”

Section: Discussionmentioning

confidence: 99%

Unilateral Diffuse Alveolar Hemorrhage Due to Selective Directionality of Mitral Regurgitant Jet in a Patient With Severe Aortic Stenosis

Saha¹,

Chong²,

Saha³

2021

Cureus

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“…Stachybotrys chartarum toxin (satratoxin) has been implicated in the pathogenesis of IPH because of its capability to inhibit collagen IV synthesis and, therefore, angiogenesis and pulmonary capillary basement membrane formation in children. 19 A quarter of patients with IPH/PH present with autoantibodies such as anti-smooth muscle (ASM), anti-neutrophil cytoplasmic antibody (ANCA), anti-nuclear antibody (ANA), rheumatoid factor (RF), and anti-cyclic citrullinated peptide antibody (anti-CCP). 19 The incidence of IPH is estimated between 0.24 and 1.26 patients per million (prevalence 6.71 cases per 1 000 000 patients), affecting children between 1 and 7 years of age.…”

Section: Pulmonary Hemosiderosis and Idiopathic Pulmonary Hemosiderosismentioning

confidence: 99%

“…19 A quarter of patients with IPH/PH present with autoantibodies such as anti-smooth muscle (ASM), anti-neutrophil cytoplasmic antibody (ANCA), anti-nuclear antibody (ANA), rheumatoid factor (RF), and anti-cyclic citrullinated peptide antibody (anti-CCP). 19 The incidence of IPH is estimated between 0.24 and 1.26 patients per million (prevalence 6.71 cases per 1 000 000 patients), affecting children between 1 and 7 years of age. 19,20 Presentation in adulthood has, however, been reported in 20% of the cases.…”

Section: Pulmonary Hemosiderosis and Idiopathic Pulmonary Hemosiderosismentioning

confidence: 99%

“…Secondary PH and vasculitis should be excluded. 19 Therapy is supportive (ie, blood transfusion), based on corticosteroids as first line, and second line immunosuppressants such as hydroxychloroquine, azathioprine, and cyclophosphamide, intravenous immunoglobulin, and leflunomide. Plasmapheresis and mesenchymal stem cell transplantation have been effective in a minority of patients.…”

Section: Pulmonary Hemosiderosis and Idiopathic Pulmonary Hemosiderosismentioning

confidence: 99%

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Congenital interstitial lung diseases: What the anesthesiologist needs to know

Bertolizio

Engelhardt

Veyckemans

2021

Pediatric Anesthesia

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Congenital interstitial lung diseases can affect both adults and children. Pediatric congenital interstitial lung diseases generally carry high risk for morbidly and mortality and include congenital alveolar capillary dysplasia with misalignment of pulmonary veins, congenital alveolar dysplasia, acinar dysplasia, congenital pulmonary lymphangiectasis, diffuse pulmonary lymphangiomatosis, neuroendocrine cell hyperplasia of infancy, pulmonary hemosiderosis, pulmonary alveolar proteinosis, and pulmonary interstitial glycogenosis. Given their usual non-specific clinical presentation, they are frequently misdiagnosed and recognized late, particularly in children who have been apparently healthy for several years (eg, diffuse pulmonary lymphangiomatosis). Some diseases have a very poor prognosis, whereas others have a benign course with appropriate treatment. The current manuscript reviews congenital interstitial lung diseases that typically affect neonates and young children and may be encountered by the pediatric anesthesiologist.

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Idiopathic pulmonary hemosiderosis: A state of the art review

Cited by 47 publications

References 77 publications

Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence

Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence

Unilateral Diffuse Alveolar Hemorrhage Due to Selective Directionality of Mitral Regurgitant Jet in a Patient With Severe Aortic Stenosis

Congenital interstitial lung diseases: What the anesthesiologist needs to know

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