Idiopathic pulmonary haemosiderosis: spectrum of thoracic imaging findings in the adult patient

Khorashadi, Leila; Wu, Carol C.; Betancourt, Sonia L.; Carter, B.W.

doi:10.1016/j.crad.2014.11.007

Cited by 31 publications

(43 citation statements)

References 45 publications

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“…A recent review of IPH thoracic imaging showed pulmonary fibrosis and honeycombing in the basilar and subpleural lower lobe regions in an end‐stage patient . Conversely, the progression of fibrosis and cystic lesions in the present case was mainly observed in the upper lobe of the lung even though haemoptysis and anaemia had been suppressed by steroid therapy.…”

Section: Discussioncontrasting

confidence: 49%

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Long‐term clinical course of idiopathic pulmonary haemosiderosis with rheumatoid arthritis

Sugimoto

Terada

Naito

et al. 2016

Respirology Case Reports

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Idiopathic pulmonary haemosiderosis (IPH) is a rare cause of diffuse alveolar haemorrhage during childhood, and its precise pathophysiology and long‐term clinical course remain unclear. A 31‐year‐old man was diagnosed with IPH at four years of age and had recurrent episodes of haemoptysis. The patient's symptoms responded well to steroids. However, pulmonary fibrosis and the cystic region in the lung progressively worsened. At age 27, the patient developed polyarthritis with positive anti‐cyclic citrullinated peptide antibodies. The patient also developed hand synovitis, which was diagnosed with ultrasonography. These results indicate complications from rheumatoid arthritis. The patient's dyspnoea gradually worsened, and at the age of 31, he developed pneumothorax and an acute exacerbation of IPH. The clinical course from ages 4 to 31 included progressive chronic respiratory failure because of pulmonary fibrosis, acute exacerbations, complications with rheumatoid arthritis, and deliberation regarding lung transplantation. The development of rheumatoid arthritis after the onset of IPH supports the theory of an autoimmune mechanism of IPH.

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Section: Discussioncontrasting

confidence: 49%

“…A recent review of IPH thoracic imaging showed pulmonary fibrosis and honeycombing in the basilar and subpleural lower lobe regions in an end-stage patient [6].…”

Section: Discussionmentioning

confidence: 98%

Long‐term clinical course of idiopathic pulmonary haemosiderosis with rheumatoid arthritis

Sugimoto

Terada

Naito

et al. 2016

Respirology Case Reports

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“…It is well known that the presence of selective IgA deficiency is associated with an increased incidence of autoimmune diseases. The absence of secretory IgA in the mucosal surfaces compromises mucosal integrity, thus allowing for increased passage of environmental antigens into the systemic circulation, and these antigens may result in cross‐reactions with self‐antigens . Eventually, IgA plays an essential role in mucosal immunity, and in light of its association with other autoimmune disorders, it is likely that this deficiency may be a contributing factor in the development of pulmonary hemosiderosis in our patient.…”

Section: Discussionmentioning

confidence: 90%

Unusual presentation: Concurrent IgA deficiency and idiopathic pulmonary hemosiderosis

Erkoçoğlu

Civelek

Kocabaş

2016

Pediatric Pulmonology

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Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder that should be considered in the differential diagnosis of patients with hemoptysis, recurrent alveolar hemorrhage, dyspnea and iron deficiency anemia (IDA). The frequent association of autoimmune disorders with IPH and a favorable response to steroids suggest the presence of an underlying immune disorder. Here we present a case of a patient with cough, fever, and cyanosis who was also diagnosed with IPH and concurrent selective immunoglobulin A deficiency. This presentation is a unique presentation because of the co-occurrence of these two disorders. Pediatr Pulmonol. 2016;51:E34-E36. © 2016 Wiley Periodicals, Inc.

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“…However, the number of feline cases was relatively small, limiting the conclusions that could be drawn regarding the association of hemosiderosis with particular conditions, types of pulmonary disease, and the absence of pulmonary disease. A cause for pulmonary hemosiderosis is not always identified in humans, and various environmental factors such as inhalation of mold spores have been implicated . Although chronic exposure to toxic mold has been associated with severe pulmonary hemorrhage under anesthesia in two cats, a potential relationship between environmental agents and frequency of hemosiderosis in cats and dogs remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…The conditions prior to BAL procedures that were specifically recorded were the presence of gastrointestinal (GI) diseases, autoimmune diseases, neoplasia, and osteoarthrosis. These diseases have been reported to be associated with pulmonary hemosiderosis in human medicine . A previous diagnosis of GI disease was based on vomiting and/or diarrhea for a 1‐week duration or longer.…”

Section: Methodsmentioning

confidence: 99%

Bronchoalveolar lavage hemosiderosis in dogs and cats with respiratory disease

Hooi

Defarges

Jelovcic

et al. 2019

Veterinary Clinical Pathol

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Background: Hemosiderophages can be found in bronchoalveolar lavage samples and have been reported in association with a wide range of respiratory and cardiovascular disorders in cats and humans.Objectives: This study aimed to retrospectively evaluate the presence of hemosiderin in canine and feline bronchoalveolar lavage (BAL) samples. It also aimed to examine the association of BAL hemosiderin with signalment, clinical signs, and historical disease prior to BAL, with prior transthoracic fine-needle aspiration (FNA), with bronchoalveolar lavage duration, and with cytologic interpretation. Methods:The medical records of dogs and cats with respiratory disease that underwent BAL between 2007 and 2016 were reviewed. Appropriate medical information and BAL results were available from 171 dogs and 34 cats. Cases were assigned to four disease categories based on BAL cytologic findings: pneumonia, inflammatory disease, neoplasia, or normal airways. The degree of hemosiderosis was classified based on a semi-quantitative scoring scale. Exact logistic regression analysis was used to evaluate the relationship between risk factors and the presence of BAL hemosiderosis on cytology. Results:Hemosiderin was identified in 13/171 (7.6%) canine samples and 18/34 (52.9%) feline samples. Cats were 13.33 times more likely to have pulmonary hemosiderosis on bronchoalveolar lavage cytology compared with dogs (P < 0.001).Increased respiratory rates, prolonged bronchoalveolar lavage times, concurrent transthoracic FNAs, and cytologic diagnoses were associated with an increased risk of hemosiderosis in dogs. No specific risk factors associated with pulmonary hemosiderosis in cats were identified. Conclusions:Hemosiderosis is more common in BAL samples from cats than from dogs and is associated with a diverse range of disease conditions. K E Y W O R D Scanine, feline, hemosiderophage, hemosiderosis, pulmonary, respiratory disease

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Idiopathic pulmonary haemosiderosis: spectrum of thoracic imaging findings in the adult patient

Cited by 31 publications

References 45 publications

Long‐term clinical course of idiopathic pulmonary haemosiderosis with rheumatoid arthritis

Long‐term clinical course of idiopathic pulmonary haemosiderosis with rheumatoid arthritis

Unusual presentation: Concurrent IgA deficiency and idiopathic pulmonary hemosiderosis

Bronchoalveolar lavage hemosiderosis in dogs and cats with respiratory disease

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