Idiopathic pulmonary fibrosis and intestinal disorders: An observational study

Caramaschi, Stefania; Bertani, A.; Cerri, Stefania; Colecchia, Antonio; Andrea, Ambrosini-Spaltro; Manco, Gianrocco; Salviato, Tiziana; Luca, Reggiani Bonetti

doi:10.1016/j.anndiagpath.2022.152072

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…The researchers analyzed a database of 189 IPF patients living in the Modena area, consisting of 148 males (78.3%) and 41 females (21.7%). From this database, they were able to identify 44 patients (36 males, 81.8%; 8 females, 18.2%) who had a confirmed diagnosis of a gastrointestinal disease based on their histological features ( Stefania et al., 2023 ). Experiments conducted on mice have shown that early-life exposure to antibiotics, leading to disruption of the gut microbiome, can promote the development of skin and lung fibrosis later in life ( Ho and Varga, 2017 ).…”

Section: Gut-lung Axis and Pulmonary Fibrosismentioning

confidence: 99%

The mechanism of gut-lung axis in pulmonary fibrosis

Dong,

He,

Zhu

et al. 2024

Front. Cell. Infect. Microbiol.

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Pulmonary fibrosis (PF) is a terminal change of a lung disease that is marked by damage to alveolar epithelial cells, abnormal proliferative transformation of fibroblasts, excessive deposition of extracellular matrix (ECM), and concomitant inflammatory damage. Its characteristics include short median survival, high mortality rate, and limited treatment effectiveness. More in-depth studies on the mechanisms of PF are needed to provide better treatment options. The idea of the gut-lung axis has emerged as a result of comprehensive investigations into the microbiome, metabolome, and immune system. This theory is based on the material basis of microorganisms and their metabolites, while the gut-lung circulatory system and the shared mucosal immune system act as the connectors that facilitate the interplay between the gastrointestinal and respiratory systems. The emergence of a new view of the gut-lung axis is complementary and cross-cutting to the study of the mechanisms involved in PF and provides new ideas for its treatment. This article reviews the mechanisms involved in PF, the gut-lung axis theory, and the correlation between the two. Exploring the gut-lung axis mechanism and treatments related to PF from the perspectives of microorganisms, microbial metabolites, and the immune system. The study of the gut-lung axis and PF is still in its early stages. This review systematically summarizes the mechanisms of PF related to the gut-lung axis, providing ideas for subsequent research and treatment of related mechanisms.

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Section: Gut-lung Axis and Pulmonary Fibrosismentioning

confidence: 99%

The mechanism of gut-lung axis in pulmonary fibrosis

Dong,

He,

Zhu

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by the formation of tissue wounds in the lungs and progressive dyspnea, which can lead to death. The mechanism is progressive connective tissue deposition in the lung interstitials and wound formation, replacing healthy lung tissue [1]. There are an estimated 3.2 million cases of IPF globally and 1.22 million new cases each year, according to the World IPF Joint Association.…”

Section: Introduction mentioning

confidence: 99%

Elephantopus scaber L. Ethanolic Leaves Extract Modulates IL-2 Production and T-Lymphocyte Activation in Pulmonary Fibrosis Mice Model

Izzah,

Christina,

Dwijayanti

et al. 2024

JELS

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Pulmonary fibrosis is a chronic disease characterized by progressive connective tissue deposition that replaces healthy lung tissue. This study aimed to investigate the effect of Elephantopus scaber L. Ethanol Extract (ESEE) treatment on the relative number of IL-2 cytokine and lymphocyte activation in bleomycin (BLM)-induced pulmonary fibrosis mice model. Fifty-six male BALB/c mice were divided into seven treatment groups: N (normal); V or vehicle (corn oil); PF or Pulmonary Fibrosis (BLM 2 mg.kg -1 ); Dex (Dexamethasone 3 mg.kg -1 + BLM); D1-D3 (ESEE at doses of 0.0504, 0.1008, and 0.2016 mg.kg -1 BW + BLM). ESEE, dexamethasone, and corn oil were administered orally, followed by intraperitoneal bleomycin injection daily for 14 days. Mice were dissected on days 7 and 14, and spleens were isolated to analyze cell populations expressing CD4 + IL-2 + , CD8 + IL-2 + , CD4 + CD62L + , and CD8 + CD62L + . The results showed that bleomycin injection could increase the relative number of IL-2 and decrease the relative number of naive T cells compared to normal mice. ESEE treatment significantly reduced the relative number of IL-2, thus decreasing naive T cell activation after one week of bleomycin injection compared to the mice model. In contrast, the increased IL-2 production led to the increasing naive T cell activation after two weeks of bleomycin injection. Therefore, ESEE treatment has the potential to maintain homeostasis through modulation of IL-2 production and T-lymphocyte activation in the pulmonary fibrosis mice model.

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“…There are no case reports until now following minimally invasive surgeries or following polypectomies. A preliminary study has observed incidence of polyps to be as high as 20% in IPF patients with improved survival due to enhanced diagnostics and novel therapies 6. This highlights the importance of investigating the effect of nintedanib on polypectomy site healing.…”

Section: Introductionmentioning

confidence: 99%

Delayed healing of rectal mucosa after endoscopic submucosal dissection (ESD) with nintedanib use

Yalamarthi,

Alipouriani,

Savage

et al. 2023

BMJ Case Rep

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Nintedanib is a novel antifibrotic agent used in the treatment of interstitial lung diseases. It has been associated with delayed wound healing and wound dehiscence in case reports after major surgeries when used perioperatively. This report presents an unprecedented case of a non-healing ulcer following an endorobotic submucosal dissection of a recurrent, adenomatous rectal polyp, likely due to nintedanib use. In this article, key components of the case were described with the aim to highlight a noteworthy differential diagnosis when suspecting recurrent rectal polyps as well as the need for further research on the effects of nintedanib on healing of polypectomy sites postoperatively.

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Idiopathic pulmonary fibrosis and intestinal disorders: An observational study

Cited by 3 publications

References 25 publications

The mechanism of gut-lung axis in pulmonary fibrosis

The mechanism of gut-lung axis in pulmonary fibrosis

Elephantopus scaber L. Ethanolic Leaves Extract Modulates IL-2 Production and T-Lymphocyte Activation in Pulmonary Fibrosis Mice Model

Delayed healing of rectal mucosa after endoscopic submucosal dissection (ESD) with nintedanib use

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